Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome
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Exercise The architectonic space is an exercise in architecture. It invites students to follow a particular approach to design that, for pedagogical purposes, limits the number of questions considered, in order to privilege a specific dimension of architec ...
Gene transcription is essential for the establishment and the maintenance of long-term memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that control gene transcription in neuronal cells are complex and recruit multip ...
In this paper, we explore the possibility of a general framework for modelling engagement dynamics in software tutoring, focusing on the cases of developmental dyslexia and developmental dyscalculia. This project aims at capturing the similar engagement st ...
Down syndrome (DS) is the most frequent cause of mental retardation in adults and children. It has been proposed that cognitive disabilities associated with DS may be ascribed to neurogenesis impairment during both development and adulthood. This view is s ...
The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative lifespan in budding yeast and was subsequently shown to modulate longevity in worms and flies. Its mammalian homologue, SIRT1, seems to have evolved complex systemic r ...
This paper describes the European Commission (EC) Framework 7 funded project myCopter (2011-2014). The project is still at an early stage so the paper starts with a discussion of the current transportation issues faced, for example, by European countries a ...
Since its introduction 16 years ago, the astrocyte-neuron lactate shuttle (ANLS) model has profoundly modified our understanding of neuroenergetics by bringing a cellular and molecular resolution. Praised or disputed, the concept has never ceased to attrac ...
Down syndrome (DS) is the most frequent cause of cognitive disability in children and adults. It has been reported that defects in neurogenesis occur both during development and adulthood and possibly underlie cognitive dysfunction associated with DS. Rece ...
Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in th ...
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is believed to be an important regulator of striatal neuron survival, differentiation, and plasticity. Moreover, reduction of BDNF delivery to the striatum has been implicated in the pathophysiology of H ...
