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A bioactive injectable bulking material; a potential therapeutic approach for stress urinary incontinence
Related publications (36)
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle
Martinus Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...
eLIFE SCIENCES PUBL LTD2023A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle
Bart Deplancke, Julie Marie Russeil, Sonia Karaz, Maria Deak, Umji Lee, Benjamin D. Cosgrove
Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and meta-bolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel regulator ...
CELL PRESS2022Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity
Johan Auwerx, Umberto De Marchi
Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...
NATURE PORTFOLIO2021Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020The gut microbiota influences skeletal muscle mass and function in mice
Johan Auwerx, Hongbo Zhang, Walter Wahli
The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...
AMER ASSOC ADVANCEMENT SCIENCE2019Mitochondria! function is impaired in the skeletal muscle of pre-frail elderly
Johan Auwerx, Pénélope Andreux
Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia. While these two conditions are well characterized, further investigation of the early biological ...
2018Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle
Johan Auwerx, Carlos Canto Alvarez, Xu Wang, Pooja Jha, Chiara Greggio
Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiova ...
Cell Press2017Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro
Jonathan Paz Montoya, Marc Moniatte, Frédéric Bruno Martin Gachon, Howard Riezman, Benjamin Dieter Weger
Circadian clocks play an important role in lipid homeostasis, with impact on various metabolic diseases. Due to the central role of skeletal muscle in whole-body metabolism, we aimed at studying muscle lipid profiles in a temporal manner. Moreover, it has ...
Natl Acad Sciences2017An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondria! metabolism
Johan Auwerx, Pénélope Andreux, Xu Wang
Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are ...
Elsevier Science Bv2017Optimization of thin-film highly-compliant elastomer sensors for contractility measurement of muscle cells
Herbert Shea, Cristina Martin Olmos, Matthias Imboden, Samuel Rosset, Alexandre Poulin, Mélanie Favre, Oluwaseun Adelowo Araromi, Francesca Sorba
Test assays capable of providing quantitative characterization of the contraction of cardiac and smooth muscle cells are of great need for drug development and screening. Several methodologies have been proposed for achieving measurement of cell contractil ...
Elsevier Science Bv2016