Modular interface and experimental setup for in-vacuum operation of microfluidic devices
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A multiplexed immunoassay-based antibiotic sensing device integrated in a lab-on-a-chip format is described. The approach is multidisciplinary and involves the convergent development of a multi-antibiotic competitive immunoassay based on sensitive waveleng ...
Purification of magnetic microparticles was demonstrated, with a purification efficiency of (72±14) % at a flow rate of 3 μl/min, in a microfluidic chip using a rotational magnetic system under continuous flow conditions. The rotation of a periodically arr ...
We attempted ultrasonic welding as a technique for the bonding of connectors to microfluidic devices. Different schemes of the method were explored based on different designs of the connectors to achieve a strong, minimal dead-volume connection. Results sh ...
In this paper, we demonstrate a bead-based microfluidic immunoassay using self-assembled streptavidin-coated bead micropatterns. The beads are assembled on the microfluidic channel surface using electrostatic forces between the negatively-charged streptavi ...
We form water-in-oil droplets in a microfluidic channel-nozzle geometry for studying the influence of viscosity of oil and of different oil classes on the droplet size. We find that the chemical structure of oil dominates over its viscosity. Our studies ar ...
Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009
Since the introduction of the of Micro Total Analysis Systems concept in 1990, important progress in microfluidic analytical systems has been realized. In many cases, microfluidic systems have shown improved analytical performances over classical methods, ...
Low-cost and high-resolution on-chip microscopes are vital for reducing cost and improving efficiency for modern biomedicine and bioscience. Despite the needs, the conventional microscope design has proven difficult to miniaturize. Here, we report the impl ...
We present leakage-free valves and an efficient fixed-volume mixer fabricated using a four-layer soft lithography technique in polydimethylsiloxane (PDMS). Mixing is achieved with a 95% efficiency in a few seconds by creating circular flow patterns inside ...
Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009
[...] During this project, the fusion feasibility of chips produced for other applications have been tested and some critical fusion parameters have been defined. Then, with the help of FEM simulations, a new chip design has been proposed to overcome the p ...
This thesis reports on the development of technologies and methods for a microfiuidic device for continuous pressure-driven flow-injection analysis. Chip based, pressure-driven liquid chromatographic (LC) systems are often avoided due to the difficulties e ...