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The standard model (SM) production of four top quarks () in proton-proton collision is studied by the CMS Collaboration. The data sample, collected during the 2016-2018 data taking of the LHC, corresponds to an integrated luminosity of 137 fb at a center-of-mass energy of 13 TeV. The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets. The observed and expected significances for the signal are respectively 2.6 and 2.7 standard deviations, and the cross section is measured to be 12.6 fb. The results are used to constrain the Yukawa coupling of the top quark to the Higgs boson, , yielding a limit of $|{y_{\mathrm{t}}/y_{\mathrm{t}}^{\mathrm{SM}}}|
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