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A Delta Sigma-Modulated Sample and Average Common-Mode Feedback Technique for Capacitively Coupled Amplifiers in a 192-nW Acoustic Analog Front-End

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Low-Noise, High-Density Microelectronics for Multi-Mode Screening of Excitable Biological Cells

Urs Alexander Müller

In the past decades, two recording tools have established themselves as the working horses in the field of electrophysiological cell research: the microelectrode array (MEA) and the optical fluorescence imaging. The former is a grid of miniature electrodes ...

EPFL2012

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The design of a high-density neural recording system targeting epilepsy monitoring is presented. Circuit challenges and techniques are discussed to optimize the amplifier topology and the included OTA. A new platform supporting active recording devices tar ...

Ieee2012

We demonstrate an analytical method for calculating the phase sensitivity of a class of oscillators whose phase does not affect the time evolution of the other dynamic variables. We show that such oscillators possess the possibility for complete phase nois ...

2012

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A topology for the calibration of DAC errors in multi-bit sigma delta modulators is presented. The proposed technique enables the calibration to proceed in the background. In this technique, two DACs are used in a time-interleaved fashion. One DAC is calib ...

2012

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This paper presents a neural recording amplifier array suitable for large-scale integration with multielectrode arrays in very low-power microelectronic cortical implants. The proposed amplifier is one of the most energy-efficient structures reported to da ...

2011

Amplitude modulation based readout for very dense active microelectrode arrays

Alexandre Schmid, Yusuf Leblebici, Neil Joye

A readout method which is suitable for high-density active microelectrode arrays used in electrophysiology experiments is presented. Amplitude modulation of consecutive channels enables simultaneous recording and transmission of the signals recorded on mul ...

2011

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In this paper, the design of a low-noise amplifier (LNA) for a 32x32 pixel microelectrode array (MEA) is presented. Its gain and noise amount to 50 dB and 10 Vrms, respectively, at a bandwidth of 66 kHz. The LNA consumes less than 85 uW. The integrated off ...

2011

Increased Speed: 3D Silicon Sensors; Fast Current Amplifiers

Matthieu Despeisse

The authors describe techniques to make fast, sub-nanosecond time resolution solid-state detector systems using sensors with 3D electrodes, current amplifiers, constant-fraction comparators or fast wave-form recorders, and some of the next steps to reach s ...

2011

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An innovative readout channel, based on analog amplitude modulation (AM) of the signals recorded by each electrode, is developed for high-density CMOS-based MEAs. This new readout method enables the design of a low-noise amplification stage while still rea ...

2010

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A prototype of a high-density multielectrode array for in vitro recording of electrogenic cell networks has been developed. On a surface of 1.92x1.92mm2, it includes 32x32 pixels with a dimension of 60x60µm2. For local amplification of the sensed extracell ...

2010