Plasmonic Nanohole Arrays on Hybrid Substrate For Highly Sensitive Label-Free Biosensing

A biosensor device including a metal layer, a transparent substrate layer, and a dielectric layer, wherein the metal layer includes a plurality of sub-wavelength apertures, and wherein the dielectric layer is located between the metal layer and the transparent substrate layer to form a spectrally isolated and well-defined optical transmission resonance through the extraordinary optical transmission (EOT) phenomenon.