Publication
Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability
Related publications (73)
Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations
Ex-vivo drug sensitivity screening (DSS) allows the prediction of cancer treatment effectiveness in a personalized fashion. However, it only provides a readout on mixtures of cells, potentially occulting important information on clinically relevant cell su ...
EPFL2024Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma
Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Irina Sinenko, Patrik Aouad
Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...
WILEY2023The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma
Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson
Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023Alchemical analysis of FDA approved drugs
Philippe Schwaller, Daniel Probst, Jean-Louis Reymond, Markus Orsi
Chemical space maps help visualize similarities within molecular sets. However, there are many different molecular similarity measures resulting in a confusing number of possible comparisons. To overcome this limitation, we exploit the fact that tools desi ...
2023Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy
Monia Guidi, Nadia Terranova, Federico Amato, Daniel Abler, Olivier Michielin, Alexandre Wicky
The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...
2023Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital
Corinne Scaletta, Philippe Abdel Sayed, Nathalie Hirt-Burri, Alexis Laurent, Vincent Gremeaux
Platelet-rich plasma (PRP) preparations have recently become widely available in sports medicine, facilitating their use in regenerative therapy for ligament and tendon affections. Quality-oriented regulatory constraints for PRP manufacturing and available ...
MDPI2023Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
Andrea Pfeifer, Florence Gauye, Tariq Afroz, Monisha Ratnam
Optimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients. To accomplish this, we followed an approach comprising structure-based mAb charge engineering in ...
TAYLOR & FRANCIS INC2023Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma
The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...
EPFL2022Rational design of protein switches: applications in synthetic biology and cancer immunotherapy
Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...
EPFL2022A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets
Christoph Merten, Vida Vafaizadeh, Wenwei Ma
Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell genetics, antibody discovery and directed evolution. All these applications make use of genetic libraries, illustrating the difficulty of generating che ...
NATURE PORTFOLIO2022