Artificial intelligence for natural product drug discovery
Graph Chatbot
Chat with Graph Search
Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.
DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.
Artificial intelligence (AI) plays a rapidly increasing role in clinical care. Many of these systems, for instance, deep learning-based applications using multilayered Artificial Neural Nets, exhibit epistemic opacity in the sense that they preclude compre ...
Tricyclic peptides have reduced conformational flexibility, making them well suited for ligand development. Researchers have now generated large combinatorial libraries of tricyclic peptides using a disulfide-directing motif. Screening these libraries disc ...
Explainable Artificial Intelligence (XAI) plays a crucial role in enabling human understanding and trust in deep learning systems, often defined as determining which features are most important to a model's prediction. As models get larger, more ubiquitous ...
The photochemical thiol-ene reaction is an efficient method for rapid and chemoselective formation of thioether linkages under mild conditions. It has found widespread use in small-molecule synthesis as well as peptide and protein chemistry. While high-thr ...
Following the hugely successful application of deep learning methods to protein structure prediction, an increasing number of design methods seek to leverage generative models to design proteins with improved functionality over native proteins or novel str ...
Artificial intelligence and machine learning algorithms have become ubiquitous. Although they offer a wide range of benefits, their adoption in decision-critical fields is limited by their lack of interpretability, particularly with textual data. Moreover, ...
In this paper, we propose and compare personalized models for Productive Engagement (PE) recognition. PE is defined as the level of engagement that maximizes learning. Previously, in the context of robot-mediated collaborative learning, a framework of prod ...
The ability to forecast human motion, called ``human trajectory forecasting", is a critical requirement for mobility applications such as autonomous driving and robot navigation. Humans plan their path taking into account what might happen in the future. S ...
An unprecedent asymmetric catalytic benzilic amide rearrangement for the synthesis of a,a-disubstituted piperazinones is reported. The reaction proceeds via a domino [4+1] imidazolidination/formal 1,2-nitrogen shift/1,2-aryl or alkyl migration sequence, em ...
