Publication
Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset
Abstract
1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats received a drug-free solution), suspension group (rats received a suspension of 2-octynoHA; 30 mg/kg, twice daily), solution group (rats received a solution of 2-octynoHA, 30 mg/kg, twice daily) and capsule group (rats received 2-octynoHA in enteric capsules; 10 mg once daily). 1H MRS measurements were performed on day 39 post-BDL surgery corresponding to the last day of treatment. The dataset contains RAW spectra (metabolites and water) prepared for LCModel quantification. Funded by Carigest
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