Publications related to Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

Metals in Proteins: Correlation Between the Metal-Ion Type, Coordination Number and the Amino-Acid Residues Involved in the Coordination

Metal ions are constituents of many metalloproteins, in which they have either catalytic (metalloenzymes) or structural functions. In this work, the characteristics of various metals were studied (Cu, Zn, Mg, Mn, Fe, Co, Ni, Cd and Ca in proteins with know ...

2008

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

Lothar Helm, Alain Borel, Loïck Moriggi

Electron-spin relaxation is one of the determining factors in the efficacy of MRI contrast agents. Of all the parameters involved in determining relaxivity it remains the least well understood, particularly as it relates to the structure of the complex. On ...

2008

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

A novel ligand, H12L, based on a trimethylbenzene core bearing three methylenediethylenetriamine-N,N,N,N- tetraacetate moieties (–CH2DTTA4–) for Gd3+ chelation has been synthesized, and its trinuclear Gd3+ complex [Gd3L(H2O) 6]3– investigated with respect ...

2008

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Oleg Yazyev

The phenomenon of magnetism is one of the key components of today's technological progress. Magnetic interactions and magnetic materials are essential for the scientific disciplines of physics, chemistry and biology, making this subject truly multidiscipli ...

EPFL2007

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Jean-Claude Bünzli, Caroline Vandevyver

A new polydentate tripodal ligand T2soxMe was synthesized to take advantage of the chelating effect of tridentate 8- hydroxyquinolinate subunits. Potentiometric and spectrophotometric titrations reveal seven pKa values of between 3.7 and 10.2. In water, th ...

2007

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Lothar Helm, Oleg Yazyev

We applied first principles molecular dynamics (MD) technique to study structure, dynamics, and magnetic interactions of the

Gd^{3+}

aqua ion dissolved in liquid water, a prototypical system for Gd-based complexes used as contrast agents for magnetic res ...

2007

A Starburst-Shaped Heterometallic Compound Incorporating Six Densely Packed Gd3+ Ions

André Merbach, Alain Borel, Eva Jakab Toth, Joao Bruno Livramento Fig.

The heterotritopic ligand [bpy(DTTA)2]8- has two diethylenediamine-tetraacetate units for selective lanthanide(III) coordination and one bipyridine function for selective FeII coordination. In aqueous solution and in the presence of these metals, the ligan ...

2006

NIR Lanthanide Luminescence by Energy Transfer from Appended Terpyridine-Boradiazaindacene Dyes

Rosario Scopelliti, Jean-Claude Bünzli

Mononuclear trivalent lanthanide complexes with formula [Ln(L)(NO3)3] [in which L=4,4-difluoro-8-(2:2;6:2-terpyridin-4-yl)-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (Boditerpy)] are reported for Ln=Yb, Nd, Er, La and Gd. According to th ...

2006

Novel chelators for MRI applications

In the last two decades, Magnetic Resonance Imaging (MRI) has evolved into one of the most powerful techniques in diagnostic clinical medicine and biomedical research. MRI is primarily used to produce anatomical images, but may also give information on the ...

EPFL2006

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

Magnetic Resonance Imaging (MRI) offers an amazing number of ways to probe the human body. It is a wonderful symbiosis of engineering, science and medicine. The power of MRI is its ability to probe a variety of physical mechanisms that can then not only re ...

EPFL2006

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

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Metals in Proteins: Correlation Between the Metal-Ion Type, Coordination Number and the Amino-Acid Residues Involved in the Coordination

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

A Starburst-Shaped Heterometallic Compound Incorporating Six Densely Packed Gd3+ Ions

NIR Lanthanide Luminescence by Energy Transfer from Appended Terpyridine-Boradiazaindacene Dyes

Novel chelators for MRI applications

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Metals in Proteins: Correlation Between the Metal-Ion Type, Coordination Number and the Amino-Acid Residues Involved in the Coordination

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

A Starburst-Shaped Heterometallic Compound Incorporating Six Densely Packed Gd3+ Ions

NIR Lanthanide Luminescence by Energy Transfer from Appended Terpyridine-Boradiazaindacene Dyes

Towards the Rational Design of MRI Contrast Agents: Electron Spin Relaxation Is Largely Unaffected by the Coordination Geometry of Gadolinium(III)-DOTA-Type Complexes

A benzene-core trinuclear GdIII complex: towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

Novel chelators for MRI applications