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Multiple functions of Notch signaling in self-renewing organs and cancer

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Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling

Johannes Alexander Mosig

Adult stem cells are characterized by their unique ability to self-renew and give rise to a progeny of specialized/differentiated cells. Therefore, they have a remarkable potential for regenerative medicine. However, the use of adult stem cells is restrain ...

EPFL2013

DNA sensing unchained

Andrea Ablasser

In two recent reports in Science, James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic GMP-AMP (cGAMP), which in turn activates a signaling pathway that induces ty ...

2013

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

Freddy Radtke

Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain un ...

Wiley-Blackwell2013

Cutaneous Notch Signaling in Health and Disease

Freddy Radtke, Craig Nowell

The development and maintenance of the skin are dependent on myriad signaling pathways that regulate a variety of cellular processes. In cutaneous epithelial cells, the Notch cascade plays a central role in ensuring that proliferation and differentiation a ...

Cold Spring Harbor Lab Press, Publications Dept2013

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

Anne Grapin-Botton

Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systema ...

Company Of Biologists Ltd2012

Paracrine signaling by progesterone

Cathrin Brisken, Renuga Devi Rajaram

Steroid hormones coordinate and control the development and function of many organs and are implicated in many pathological processes. Progesterone signaling, in particular, is essential for several important female reproductive functions. Physiological ef ...

Elsevier2012

Generation and characterization of a Notch1 signaling-specific reporter mouse line

Freddy Radtke, Yann Barrandon, Rajwinder Lehal, Stéphanie Claudinot, Luca Pellegrinet

Signaling through the Notch1 receptor is essential for the control of numerous developmental processes during embryonic life as well as in adult tissue homeostasis and disease. Since the outcome of Notch1 signaling is highly context-dependent, and its prec ...

Wiley-Blackwell2012

Exploring the therapeutic space around NAD+

Johan Auwerx, Richardus Houtkooper

NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegenerati ...

Rockefeller University Press2012

The Cell Differentiation Status Influences the Outcome of Notch-Induced Malignancy

Caroline Poisson

The Notch signaling cascade is a well conserved pathway that regulates many aspects of embryonic development and plays a crucial role in the differentiation process and tissue homeostasis in multiple organs of adult species. Several human pathological diso ...

EPFL2011

The Intestinal Epithelium

Luca Pellegrinet

The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supported by proliferating progenitors located in the intestinal crypt, which is also the stem cell location. Homeostasis of the intestinal epithelium has to be ...

EPFL2011