Rapid Production of Submicron Drug Substance Particles by Supersonic Spray Drying

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Cavitation bubble dynamics and microjet atomization near tissue-mimicking materials

Mohamed Farhat, Davide Bernardo Preso, Armand Baptiste Sieber

In recent years, considerable interest has been devoted to the interactions between cavitation bubbles and tissue-mimicking materials due to their promising applications in medicine and biomedical sciences. The strong fluid-structure interaction between a ...

AIP Publishing2023

Estrogen receptor signaling in the human breast epithelium

Céline Berthe Constantin

Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...

EPFL2022

Comparative study between Cubic and Ellipsoidal Fokker-Planck kinetic models

Mohammadhossein Gorji

Motivated by improving the performance of particle-based Monte-Carlo simulations in the transitional regime, Fokker–Planck kinetic models have been devised and studied as approximations of the Boltzmann collision operator. By generalizing the linear drift ...

2019

Two-fluid plasma model for radial Langmuir probes as a converging nozzle with sonic choked flow, and sonic passage to supersonic flow

Ivo Furno, Alan Howling, Philippe Frédérique Bruno Guittienne

Using the Lambert function, Guittienne et al. [Phys. Plasmas 25, 093519 (2018)] derived two-fluid solutions for radial Langmuir probes in collisionless and isothermal plasma. In this Brief Communication, we point out the close analogy with classical compre ...

American Institute of Physics (AIP)2019

The Investigation of Flory-Huggins Interaction Parameters for Amorphous Solid Dispersion Across the Entire Temperature and Composition Range

Esther Amstad

Amorphous solid dispersion (ASD) is one of the most promising enabling formulations featuring significant water solubility and bioavailability enhancements for biopharmaceutical classification system (BCS) class II and IV drugs. An accurate thermodynamic u ...

2019

Measurements of ion velocity and wave propagation in a hollow cathode plume

The mechanism responsible for the production of energetic ions in the plume of hollow cathodes for electric propulsion is still an open issue. These ions are of concern to cathode and thruster lifetime, particularly for cathodes operating at high (>20 A) d ...

IOP PUBLISHING LTD2019

A Continuation Multi Level Monte Carlo (C-MLMC) method for uncertainty quantification in compressible inviscid aerodynamics

Fabio Nobile, Pénélope Leyland, Michele Pisaroni

In this work we apply the Continuation Multi-Level Monte Carlo (C-MLMC) algorithm proposed in Collier et al. (2014) to efficiently propagate operating and geometric uncertainties in inviscid compressible aerodynamics numerical simulations. The key idea of ...

Elsevier2017

The Role of Impeller Outflow Conditions on the Performance of Vaned Diffusers

Jürg Alexander Schiffmann

Highly loaded impellers, typically used in turbocharger and gas turbine applications, exhaust an unsteady, transonic flow that is nonuniform across the span and pitch and swirling at angles approaching tangential. With the exception of the flow angle, conf ...

American Society of Mechanical Engineers2017

Impact of rotating and fixed nozzles on vortex breakdown in compressible swirling jet flows

François Gallaire, Leonhard Kleiser

Vortex breakdown of swirling, round jet flows is investigated in the compressible, subsonic regime by means of Direct Numerical Simulation (DNS). This is achieved by solving the compressible Navier-Stokes equations on a cylindrical grid using high-order sp ...

Elsevier2016

NANOPARTICLES Production of amorphous nanoparticles by supersonic spray-drying with a microfluidic nebulator

Esther Amstad

Amorphous nanoparticles (a-NPs) have physicochemical properties distinctly different from those of the corresponding bulk crystals; for example, their solubility is much higher. However, many materials have a high propensity to crystallize and are difficul ...

American Association for the Advancement of Science2015

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