Unit
Prof. Karthaus Group
LaboratorySummary
The Unite du Prof. Karthaus, led by Wouter Richard Karthaus, focuses on studying the normal and cancer biology of steroid hormone regulated organs like the prostate, mammary gland, and endometrium. Using organoid cultures, mouse models, genomics, and single cell techniques, the lab delves into complex biological questions, particularly in normal prostate biology and therapy resistance in prostate cancer.
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Related publications (32)
A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Didier Trono, Priscilla Turelli, Evaristo Jose Planet Letschert, Filipe Amândio Brandão Sanches Vong Martins, Florian Huber, Olga Marie Louise Rosspopoff, Romain Forey, Sandra Eloise Kjeldsen, Cyril David Son-Tuyên Pulver, Joana Carlevaro Fita
Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...
2024Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond
The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...
EPFL2023Mechanism of KRAS-driven T cell infiltration in colorectal cancer
Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...
EPFL2023