Unit

Prof. Waszak Group

Laboratory
Summary

The Provisional Unity for Professor Waszak, part of the Swiss Institute for Experimental Cancer Research (ISREC) at EPFL, focuses on molecular cell biology of development and cancer, as well as basic and translational cancer research. Led by Professor Elisa Oricchio, the unit investigates genetic and epigenetic mechanisms of tumour development, cell-cell interactions in tumour microenvironments, and resistance mechanisms to cancer therapy. They employ genetically engineered mouse models, tumour-on-a-chip and organoid models, and cross-correlative analysis of clinical samples to advance understanding of cancer biology and genetics. The unit collaborates closely with other EPFL institutes, such as the Institute of Bioengineering, and is actively involved in the Swiss Cancer Center Leman (SCCL) to pioneer interdisciplinary cancer research initiatives.

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Related publications (5)

Chromatin three-dimensional interactions mediate genetic effects on gene expression

David Hacker, Giovanna Ambrosini, Philipp Bucher, Sanjeev Kumar

Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a da ...
2019

A systems approach to elucidate the genetic architecture of molecular phenotypes

Sebastian Martin Waszak

A growing body of evidence suggests that changes in gene regulatory DNA are the major genetic determinants of variation in complex phenotypes; however, the underlying genes as well as cascades of intermediate molecular events remain in most cases elusive. ...
EPFL2014

GuavaH: a compendium of host genomic data in HIV biology and disease

Jacques Fellay, Amalio Telenti, Istvan Bartha

Background: There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. We created GuavaH (Genomic Utility for Association and Viral ...
BioMed Central2014
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