Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Graham KnottGraham Knott received his degree in physiology from the University of Southampton, UK, in 1990, and his PhD in neuroscience from the University of Tasmania, Australia, in 1995. He moved to the University of Lausanne in Switzerland in 1999 where he researched the plasticity of neuronal connectivity in the adult brain, developing correlative light and electron microscopy methods for the analysis of in vivo imaged neurons. In 2006 Graham joined the Ecole Polytechnique Fédérale de Lausanne, establishing the Bio Electron Microscopy Facility and has continued his research interests in brain plasticity and 3D electron microscopy.
Jean-Claude BolaySince January 2020, Jean-Claude Bolay works as consultant, specialized in urban development in Southern countries and in scientific and academic international cooperation.Previously he was Director of the Cooperation & Development Center of EPFL (CODEV) and Professor at the Faculty of Natural, Architectural and Built Environment (ENAC). By training he is sociologist (bachelor) and political scientist (PhD from the University of Lausanne, Prize of the University of Lausanne). To reach his grade, he was awarded a scholarship from the Swiss National Foundation of Science and worked during 2 years in the postgrade Colegio de Mexico, in Mexico City (1982-83) and therefore in the Center for Latin American Studies of the UC Berkeley University, California (1984). From 1986 till 1989 he has been working as senior staff of the Swiss Agency for Development and Cooperation in the frame of a slum’ upgrading project of the World Bank and Cameroun Government in Duala, Cameroun. He was contracted by the EPFL in the frame of urban research projects in developing countries, becoming quickly the leader of several projects focused on urban upgrading actions, urban planning, social participation, urban environmental issues and governance in much diversified contexts as Burkina Faso, Bolivia, Argentina, Cuba, Ecuador, Vietnam, to cite some of them. He teaches at the master level in the Architecture section since 1995. In 2001 he was named by the President of the EPFL as responsible of the cooperation with emerging and developing countries’ partners, and therefore in 2005 as professor. He is presently leading a team of 25 scientific and administrative collaborators. He published more than 60 articles and edit several books on urban issues in developing countries as on development and scientific cooperation. He is also Director of the UNESCO Chair “Technologies for Development” and has organized 5 International Conference of the Chair focused on the links between research and operational implementation of development’ projects.https://www.mycloud.swisscom.ch/s/S00D9A9B2395F521E74EA94D2341E0A59719C7D75EB Alfio QuarteroniOf italian nationality, Alfio Quarteroni was born on May 30th 1952. He pursued his studies in mathematics at University of Pavia and at University of Paris VI. In 1986 he was nominated full professor at Catholic University of Brescia, later professor in mathematics at University of Minnesota at Minneapolis and professor in numerical analysis at Politecnico di Milano. He is designated full professor in 1997 and enters into service with EPFL in 1998. At EPFL, he teaches numerical analysis to engineers and mathematicians and holds specialized courses about mathematical modelling and scientific computing for master and PhD students. He had been scientific director of CRS4, plenary speaker of more than two hundred international conferences; he is member of the European Academy of Sciences, the Italian Academy of Sciences, the Lombard Academy of Science and Letters. He is Editor in Chief of two book series (MS&A and Unitext) by Springer, associate editor of 25 international journals. He has been plenary speaker at the International Congress of Mathematicians ICM2006. He had been responsible of several European research networks. His team has carried out the aerodynamic and hydrodynamic simulations for the optimization of Alinghi, the Swiss sailing yacht that has won two editions of the America's Cup in 2003 and 2007.
Yves WeinandBiography
Architect and civil engineer, Prof. Dr. Yves Weinand is one of the most recognised researchers in the field of contemporary wood construction. Founder of the Bureau d'Etude Weinand, he has, since 1996, designed and worked on many emblematic wooden buildings, such as the Saint Loup Chapel, the new Vaudois Parliament or, more recently, the Timber Pavilion of Vidy in Lausanne. His fundamental research questions the technical and static possibilities of wooden materials. The interdisciplinary exploration carried out at the EPFL's Laboratory for Timber Constructions (Ibois), of which he is director, concerns wood in all its aspects, from round wood to manufactured wood. The recent research carried out at Ibois on free structures with wood-wood connections (without screw nor glue) has been the subject of several technological transfers, and stands as tangible proof of new possibilities for wood construction. Yves Weinand is currently working on a large-scale project for a hall for the head office of a joinery in Luxembourg, consisting of a succession of arches with spans of 22.5 to 53.7m, entirely assembled in wood ). Through new innovative approaches, the ambition of his research is to develop a new generation of renewable and ecological wooden construction.He is regularly invited to present his work at international symposia on timber construction.
Fields of expertise
Architectural designTimber structuresDigital FabricationRobotic AssemblyStructural Wood mechanicsIntegrally Attached Timber plate structures
Distinctions
2012 Grand Prix d'Architecture de Wallonie
2014 Best Paper Award, Advances in Architectural Geometry conference. (IBOIS team)
2017 Medal for Research and Technique by the Academy of Architecture. 2018 Mention Régionale, Prix Lignum for the Timber Pavilion of Vidy-Lausanne
2019 "Disctinction Bois 2019" for the Nouveau Parlement vaudois.2019 Grand Prix d'Architecture de Wallonie____________________________________________________________________________
Selected publications
Les Cahiers de l'Ibois/ Ibois Notebooks 1, F. Fromonot, S. Berthier, Y. Rocher, publication directors: Y. Weinand et C. Catsaros, 2020 EPFL Press Le Pavillon en bois du Théâtre de Vidy, under the direction of Yves Weinand; V. Baudriller, J. Gamerro, M. Jaccard, C. Robeller; 2017, PPURAdvanced Timber Structures - Architectural Designs and Digital Dimensioning, Y. Weinand, 2017, Birkhaüser, publié en trois langues (french : Structures Innovantes en Bois (2016); german : Neue Holztragwerke - Architektonische Entwürfe und digitale Bemessung (2017)Grubenmann Project / Projekt Grubenmann, Y. Weinand, 2016, Stiftung Grubenmann-SammlungTimber Project: Nouvelles formes d’architectures en bois, Y. Weinand, 2010, PPURArchitexto, Y. Weinand and D. Darcis, 2009, Editions Fourre-Tout, LiègeLe bois soudé, B. Stamm and Y. Weinand, 2004, Architecture Bois & DépendanceNew Modeling - projeter ensemble, Y. Weinand, 2003, PPUR Ralf SeifertRalf W. Seifert is Professor of Technology & Operations Management (TOM) at the College of Management of Technology (CDM) at Ecole Polytechnique Fédérale de Lausanne (EPFL) since 2003. His primary research and teaching interests relate to operations management, supply chain strategy and technology network management. He is also active in industry analysis, international project work and new venture formation.
Based on his work with companies, Professor Seifert has co-authored more than 30 case studies covering different industries. These efforts have been recognized by multiple international case awards granted by EFMD in 2018, 2012, 2009 and 2003, ECCH in 2011 and 2006, as well as POMS in 2004. He continues to actively research issues of supply chain strategy, supply chain finance and technology management and has more than 70 articles and international conference presentations to his credit. In addition, he co-authored two books: one focused on strategic supply chain management and another one concerning start-up challenges of technology ventures.
In parallel to his appointment at EPFL, he continues to serve a position at IMD, were he has been appointed Professor of Operations Management in 2000. Prior to joining IMD, Professor Seifert studied and worked in Germany, Japan and the US. He earned PhD and MS degrees in Management Science at Stanford University, a Diplom Ingenieur degree in Mechanical Engineering at the Karlsruhe Institute of Technology (KIT) and a Master's degree in Integrated Manufacturing Systems Engineering from North Carolina State University. While in the US, he consulted for Hewlett-Packard and served as Teaching and Research Assistant at Stanford University. In Germany he worked for Booz & Company, McKinsey & Company and Freudenberg & Co. In addition, he spent one year as a Visiting Scholar in Operations Research at Waseda University in Tokyo.
Nikolaos GeroliminisProf. Nikolas Geroliminis is an Associate Professor at EPFL and the head of the Urban Transport Systems Laboratory (LUTS). Before joining EPFL he was an Assistant Professor on the faculty of the Department of Civil Engineering at the University of Minnesota. He has a diploma in Civil Engineering from the National Technical University of Athens (NTUA) and a MSc and Ph.D. in civil engineering from University of California, Berkeley. He is an Associate Editor for Transportation Research part C and he also serves in the editorial board of TR, part B, Transportation Letters, Journal of ITS and of many international conferences. He is a member of the Transportation Research Board's Traffic Flow Theory Committee. His research interests focus primarily on urban transportation systems, traffic flow theory and control, public transportation and logistics, Optimization and Large Scale Networks. He is a recent recipient of the ERC Starting Grant METAFERW: Modeling and controlling traffic congestion and propagation in large-scale urban multimodal networks
Education
Diploma, 2003, Civil Engineering, National Technical University of Athens, Greece
M.S., 2004, Civil and Environmental Engineering, University of California at Berkeley
Ph.D., 2007, Civil and Environmental Engineering, University of California at Berkeley
