Michael GraetzelProfessor of Physical Chemistry at the Ecole polytechnique fédérale de Lausanne (EPFL) Michael Graetzel, PhD, directs there the Laboratory of Photonics and Interfaces. He pioneered research on energy and electron transfer reactions in mesoscopic systems and their use to generate electricity and fuels from sunlight. He invented mesoscopic injection solar cells, one key embodiment of which is the dye-sensitized solar cell (DSC). DSCs are meanwhile commercially produced at the multi-MW-scale and created a number of new applications in particular as lightweight power supplies for portable electronic devices and in building integrated photovoltaics. They engendered perovskite solar cells (PSCs) which turned into the most exciting break-through in the history of photovoltaics. He received a number of prestigious awards, of which the most recent ones include the RusNANO Prize, the Zewail Prize in Molecular Science, the Global Energy Prize, the Millennium Technology Grand Prize, the Marcel Benoist Prize, the King Faisal International Science Prize, the Einstein World Award of Science and the Balzan Prize. He is a Fellow of several learned societies and holds eleven honorary doctor’s degrees from European and Asian Universities. His over 1500 publications have received some 220’000 citations with an h-factor of 218 (SI-Web of Science) demonstrating the strong impact of his scientific work.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Mikhail ChuraevBorn in 1995 in Moscow, Russia. Bachelor and Master degree obtained at Moscow Institute of Physics and Technology (MIPT) in 2016 and 2018. The second Master degree obtained at Skolkovo Institute of Science and Technology (Skoltech) in 2018.Mikhail joined the lab in March 2019 as a PhD student.
Viacheslav SnigirevViacheslav Snigirev was born in 1996 in Moscow. As a holder of the 1st rank degree in Lomonosov Olympiad in Physics 2014 and of the golden medal for the academic achivements in high school, he was accepted to Lomonosov Moscow State University as a bachelor student of the Department of Physics in the same year. In 2018 he defended his bachelor thesis Ultrafast dynamics of light scattering in direct-bandgap semiconductor nanoparticles under supervision of Prof. Andrey A. Fedyanin and Dr. Alexander S. Shorokhov. He then continued to carry out research under their supervision in the area of active all-dielectric metaphotonics and joined the master program Quantum Electronics and Quantum Optics at the same university, finishing it in 2020 with the master thesis title Photo- and electrically induced modulation of optical response of Mie-resonant gallium arsenide nanoparticles and metasurfaces. The both degrees are degrees with honours containing only excellent grades. The scientific results obtained within the framework of his bachelor and master programs were presented on international conferences CLEO Europe and METANANO.
Nicolai CramerNicolai Cramer est né à Stuttgart, en Allemagne ; il a étudié la chimie à l'université de Stuttgart, où il a obtenu son diplôme en 2003, et son doctorat en 2005 sous la direction du professeur Sabine Laschat. Après un stage de recherche à l'université d'Osaka, au Japon, en 2006 il a rejoint le groupe du professeur Barry M. Trost à l'université de Stanford en tant que postdoc. A partir de 2007, il a travaillé sur son habilitation à l'ETH Zurich sous la direction du Professeur Erick M. Carreira et a reçu la venia legendi en 2010. En 2010, il a été nommé comme professeur assistant à l'EPF de Lausanne et a été promu professeur associé en 2013 et professeur ordinaire en 2015. Son principal programme de recherche englobe les transformations énantiosélectives catalysées par des métaux et leur mise en œuvre pour la synthèse de molécules biologiquement actives.Profile (Angew. Chem. Int. Ed.)
CV
Philippe GilletPhilippe GILLET est entré à lEcole normale supérieure de la rue dUlm (Paris) pour y mener des études en sciences de la Terre. En 1983, il obtient un PhD en géophysique à luniversité de Paris VII et rejoint luniversité de Rennes I comme assistant. En 1988, titulaire dun doctorat dEtat, il devient professeur dans cette même université et la quitte en 1992 pour rejoindre Ecole normale supérieure de Lyon.
La formation des chaînes de montagnes, et des Alpes en particuliers, est lobjet de la première partie de sa carrière scientifique. En parallèle, il développe des techniques expérimentales (cellules à enclumes de diamants)qui permettent de simuler en laboratoire les conditions de pression et de température qui règnent au sein des planètes. Lobjectif de ces expériences est de comprendre de quels matériaux sont constituées les profondeurs inatteignables des planètes du système solaire.
En 1997, il commence à travailler sur la matière extraterrestre. Il participe à la description de météorites venant de Mars, de la Lune ou de planètes aujourdhui disparues et explique comment celles-ci ont été expulsées de leur planète dorigine par des chocs titanesques avant darriver sur Terre. Il a aussi participé au programme STARDUST de la NASA et contribué à lidentification de grains de comète ramenés sur Terre après avoir été capturés au voisinage de la comète Wild-II. Ces grains représentent les premiers minéraux de notre système solaire, formés il y a plus de 4,5 milliards dannées. Il a aussi travaillé sur les sujets suivants :
interactions entre bacteries et minéraux;
amorphisation sous pression;
techniques expérimentales: cellule à enclumes de diamant, spectroscopie Raman,diffraction des RX sur source synchrotron, microscopie électronique.
Philippe Gillet a aussi une activité de management de la science et de lenseignement. Il a ainsi dirigé lInstitut National des Sciences de lUnivers du CNRS (France), présidé le synchrotron français SOLEIL, lAgence Nationale de la Recherche française(2007) et lEcole normale supérieure de Lyon. Avant de rejoindre lEPFL il a été le directeur de cabinet du Ministre français de la Recherche et de lEnseignement Supérieur.
Quelques publications :
Ferroir, T., L. Dubrovinsky, A. El Goresy, A. Simionovici, T. Nakamura, and P. Gillet (2010), Carbon polymorphism in shocked meteorites: Evidence for new natural ultrahard phases, Earth and Planetary Science Letters, 290(1-2), 150-154
Barrat J.A., Bohn M., Gillet Ph., Yamaguchi A. (2009) Evidence for K-rich terranes on Vesta from impact spherules. Meteoritics & Planetary Science, 44, 359374.
Brownlee D, Tsou P, Aleon J, et al. (2006) Comet 81P/Wild 2 under a microscope. Science, 314, 1711-1716.
Beck P., Gillet Ph., El Goresy A., and Mostefaoui S. (2005) Timescales of shock processes in chondrites and Martian meteorites. Nature 435, 1071-1074.
Blase X., Gillet Ph., San Miguel A. and Mélinon P. (2004) Exceptional ideal strength of carbon clathrates. Phys. Rev. Lett. 92, 215505-215509.
Gillet Ph. (2002) Application of vibrational spectroscopy to geology. In Handbook of vibrational spectroscopy, Vol. 4 (ed. J. M. Chalmers and P. R. Griffiths), pp. 1-23. John Wiley & Sons.
Gillet Ph., Chen C., Dubrovinsky L., and El Goresy A. (2000) Natural NaAlSi3O8 -hollandite in the shocked Sixiangkou meteorite. Science 287, 1633-1636.
