Catégorie
Récepteur (biochimie)
Publications associées (640)
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease
Johan Auwerx, Kristina Schoonjans
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased infl ...
2007Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function
Johan Auwerx, Kristina Schoonjans
Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPARalpha) activation modulates LC function. Ou ...
2007Systematic gene expression mapping clusters nuclear receptors according to their function in the brain
Nuclear receptors (NRs) compose a large family of transcription factors that operate at the interface between genes and environment, acting as sensors and effectors that translate endocrine and metabolic cues into well-defined gene expression programs. We ...
2007Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms
Paul Joseph Dyson, Wee Han Ang, Andrew Douglas Phillips, Claudine Scolaro, Gianni Sava
Organometallic ruthenium(II) complexes of the general formula [Ru(η6-p-cymene)Cl2(L)] and [Ru(η6-p-cymene)Cl(L)2][BPh4] with modified phenoxazine- and anthracene-based multidrug resistanc ...
2007Repetitive Reversible Labeling of Proteins at Polyhistidine Sequences for Single-Molecule Imaging in Live Cells
Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Emmanuel Guignet
Sensitive live-cell fluorescence microscopy and single-molecule imaging are severely limited by rapid photobleaching of fluorescent probes. Herein, we show how to circumvent this problem using a novel, generic labeling strategy. Small nickel-nitrilotriacet ...
2007Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective
The mammary gland is a unique organ in that it undergoes most of its development after birth under the control of systemic hormones. Whereas in most other organs stem cells divide in response to local stimuli, to replace lost cells, in the mammary gland la ...
Humana Press Inc, Springer2007In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue
We generated and characterized a firefly luciferase reporter mouse for the nuclear receptor farnesoid X receptor (FXR). This FXR reporter mouse has basal luciferase expression in the terminal ileum, an organ with well-characterized FXRalpha signaling. In v ...
2007DisSIRTing on LXR and cholesterol metabolism
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear r ...
2007beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate ...
2007Single molecule detection at surfaces
Theo Lasser, Marcel Leutenegger, Kai Hassler
Fluorescence fluctuation spectroscopy based on an evanescent field excitation scheme leads to an alternative concept for single molecule detection with interesting experimental features. This concept is described and analyzed regarding the total fluorescen ...
American Chemical Society2007