Publications associées à Domaine protéique

Communication-aware adaptive parareal with application to a nonlinear hyperbolic system of partial dierential equations

Jan Sickmann Hesthaven, Allan Svejstrup Nielsen, Gilles Brunner

In the strong scaling limit, the performance of conventional spatial domain decomposition techniques for the parallel solution of PDEs saturates. When sub-domains become small, halo-communication and other overheard come to dominate. A potential path beyon ...

2017

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Florence Pojer, Oliver Hantschel, Tim Kükenshöner, Nadine Eliane Schmit

The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Src family kinases (SFKs). The high sequence conservation of the 120 human SH2 domains poses a significant c ...

2017

Ferroelectric domain continuity over grain boundaries

Dragan Damjanovic, Sukriti Mantri

Formation and mobility of domain walls in ferroelectric materials is responsible for many of their electrical and mechanical properties. Domain wall continuity across grain boundaries has been observed since the 1950's and is speculated to affect the grain ...

Elsevier2017

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

Paolo De Los Rios, Alessandro Barducci, Duccio Malinverni

Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70 ...

Elife Sciences Publications Ltd2017

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Kristen Lorentz

Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine or ...

2017

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

Brian Donal McCabe

SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the re ...

Academic Press Inc Elsevier Science2017

Hybrid proteins for the screening of transcription regulators of reductive dehalogenase gene clusters

Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin

In the past decade, research on the transcription regulation of reductive dehalogenase (rdh) gene clusters (for a recent review, see [1]) revealed a new set of CRP/FNR-type transcription regulators, called RdhK [2,3]. Several members of this family have be ...

2017

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Matteo Dal Peraro, Benoîte Bargeton

Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Mori ...

Elsevier2017

The flashlights on a distinct role of protein kinase C delta: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells

Jaroslava Joniová, Veronika Huntosova

Glioblastoma multiforme are considered to be aggressive high-grade tumors with poor prognosis for patient survival. Photodynamic therapy is one of the adjuvant therapies which has been used for glioblastoma multiforme during last decade. Hypericin, a photo ...

Elsevier2017

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Domaine protéique

Communication-aware adaptive parareal with application to a nonlinear hyperbolic system of partial dierential equations

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Ferroelectric domain continuity over grain boundaries

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

Hybrid proteins for the screening of transcription regulators of reductive dehalogenase gene clusters

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Role of Condensing Particles in Polymer Confinement: A Model for Virus-Packed "Minichromosomes"

The flashlights on a distinct role of protein kinase C delta: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells

Graph Chatbot

Chattez avec Graph Search

Ferroelectric domain continuity over grain boundaries

Role of Condensing Particles in Polymer Confinement: A Model for Virus-Packed "Minichromosomes"

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

Communication-aware adaptive parareal with application to a nonlinear hyperbolic system of partial dierential equations

Hybrid proteins for the screening of transcription regulators of reductive dehalogenase gene clusters

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

The flashlights on a distinct role of protein kinase C delta: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells

Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials