Concept

Biological computing

Publications associées (13)

Strategic Insights into Engineering Parameters Affecting Cell Type-Specific Uptake of DNA-Based Nanomaterials

Maartje Martina Cornelia Bastings, Hugo José Rodriguez Franco, Alice Comberlato, Marianna Mainardi Koga

DNA-based nanomaterials are gaining popularity as uniform and programmable bioengineering tools as a result of recent solutions to their weak stability under biological conditions. The DNA nanotechnology platform uniquely allows decoupling of engineering p ...

AMER CHEMICAL SOC2022

An Interactive Gameplay to Crowdsource Multiple Sequence Alignment of Genome Sequences: Genenigma

Comparative genomics is a field of research that compares genomes of different organisms to identify common patterns. It is a powerful method used to identify the genetic diseases that cause mutations. Multiple Sequence Alignment (MSA) is an intermediate s ...

ASSOC COMPUTING MACHINERY2019

Synthesis of Responsive Two-Dimensional Polymers via Self-Assembled DNA Networks

Duncan Thomas Lindsay Alexander, Ulrich Aschauer, Hao Yu

Despite a growing interest in two-dimensional polymers, their rational synthesis remains a challenge. The solution-phase synthesis of a two-dimensional polymer is reported. ADNA-based monomer self-assembles into a supra-molecular network, which is further ...

Wiley-V C H Verlag Gmbh2017

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

Kristina Pan Woodruff

With the advent of high-throughput and genome-wide screening initiatives, there is a need for improved methods for cell-based assays. Current approaches require expensive equipment, rely on large-scale culturing formats not suited for small or rare sample ...

EPFL2017

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Sebastian Maerkl, Kristina Pan Woodruff

Mammalian synthetic biology could be augmented through the development of high-throughput microfluidic systems that integrate cellular transfection, culturing, and imaging. We created a microfluidic chip that cultures cells and implements 280 independent t ...

Nature Publishing Group2016

Biomechanics of DNA structures visualized by 4D electron microscopy

Ulrich Lorenz

We present a technique for in situ visualization of the biomechanics of DNA structural networks using 4D electron microscopy. Vibrational oscillations of the DNA structure are excited mechanically through a short burst of substrate vibrations triggered by ...

2013

Investigation of Biophysical Properties of Biomolecules by Means of Atomic Force Microscopy

Jae Sun Jeong

Biomolecules are the building blocks of living organisms and perform the most important functions in a biological process. The aim of biophysics is to understand the biological functions of biomolecules in terms of their structure: structure and function o ...

EPFL2012

Molecular associative memory: An associative memory framework with exponential storage capacity for DNA computing

Mohammad Amin Shokrollahi, Krishna Kumar, Amir Hesam Salavati

Associative memory problem: Find the closest stored vector (in Hamming distance) to a given query vector. There are different ways to implement an associative memory, including the neural networks and DNA strands. Using neural networks, connection weights ...

2011

Reduced basis methods for Stokes equations in domains with non-affine parameter dependence

Gianluigi Rozza

In this paper we deal with reduced basis techniques applied to Stokes equations. We consider domains with different shape, parametrized by affine and non-affine maps with respect to a reference domain. The proposed method is ideally suited for the repeated ...

Springer-Verlag2009

Internal motions in biomolecules studied by NMR spectroscopy

Chiara Perazzolo

Since many biological processes occur on the μs to ms time scale, internal dynamics on that time scale is believed to be related to biological functionality. The characterization of internal dynamics is thus an important issue to improve our understanding ...

EPFL2006

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