Concept

Métabolome

Publications associées (67)

A simple model-based approach to variable selection in classification and clustering

Anthony Christopher Davison, Vahid Partovi Nia

Clustering and classification of replicated data is often performed using classical techniques that inappropriately treat the data as unreplicated, or by complex modern ones that are computationally demanding. In this paper, we introduce a simple approach ...

Wiley-Blackwell2015

Data Repository for Automated Metabolomics Administration (DRAMA)

Joana Raquel Pinto Vieira, Pierre Guy Rémy Salvy

DRAMA framework was primarily developed with the purpose of facilitating data integration into genome scale models (GEM) of cellular metabolism. The existence of differently annotated genome scale models and metabolomics datasets that are provided without ...

2015

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Martin Kussmann, Sebastiano Collino, Fiona Beguelin

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metab ...

Impact Journals Llc2014

Implications of the Assumptions on Intracellular Metabolic Operational States in Metabolic Control Analysis

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos, Keng Cher Soh, Anirikh Chakrabarti

Modeling and analysis of metabolic networks is inherently biased by assumptions regarding the intracellular metabolite and flux states. Despite the advanced metabolomics and fluxomics methods at our disposal, the sheer complexity of metabolic networks prev ...

2014

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism

Martin Kussmann, Sofia Moco

Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has risen considerably over the last decades, their clinical features do not allow accurate prediction of prognosis, likelihood of disease progression, or response to spec ...

Lippincott Williams & Wilkins2014

In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T

Rolf Gruetter, Cristina Ramona Cudalbu, Mélanie Craveiro

In 1H magnetic resonance spectroscopy, macromolecule signals underlay metabolite signals, the understanding of which is necessary for reliable metabolite quantification. When macromolecule signals are measured using an inversion-recovery pulse sequence, sp ...

Wiley-Blackwell2014

Do Carbon Nanotubes Contribute to Electrochemical Biosensing?

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Camilla Baj-Rossi

Carbon nanotubes have been attracting a lot of interest as electron transfer mediators to enhance electrochemical biosensing. The main reason behind this is usually recognized in terms of augmented electrochemical active surface area. The aim of this paper ...

Elsevier2014

Direct and selective synthesis of a wide range of carbon nanomaterials by CVD at CMOS compatible temperatures

Giovanni De Micheli, László Forró, Sandro Carrara, Arnaud Magrez, Irene Taurino

Biosensors benefit from specific nano- to monitor human metabolites [1], [2]. Moreover, small structuration of the active bio-interface layer. In this electrodes allow us to design many sensing sites, each perspective, a wide range of carbon nanomaterials ...

2014

Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu, Giulio Gambarota

OBJECT: To determine the single spin-echo T 2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. MATERIALS AND METHODS: Measurements were performed on ...

Springer Verlag2013

Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors

Giovanni De Micheli, Sandro Carrara, Eric Meurville, Cristina Boero, Andrea Cavallini, Léandre Bolomey

A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single- metabolites, an electrochemical front-end made with off-the-shelf components, a radio ...

Institute of Electrical and Electronics Engineers2013

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