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Purpose: To analyze in vivo the function of chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C (gene symbol: Cspg5) during retinal degeneration in the Rpe65(-/-) mouse model of Leber congenital amaurosis. ...
Purpose of review The discovery of a new class of intrinsically photosensitive retinal ganglion cells (ipRGCs) revealed their superior role for various nonvisual biological functions, including the pupil light reflex, and circadian photoentrainment. Recent ...
Lighting is one of the most significant factors in the built environment that affect human health and wellbeing. In addition to stimulating visual responses, light induces a range of non-visual responses in humans including synchronizing circadian rhythms ...
Suboptimal light distribution in a room can cause visual discomfort and glare. Next to rods and cones, perception of light is also governed by a third class of photoreceptors, important for circadian rhythm regulation and non-visual functions such as alert ...
EPFL Solar Energy and Building Physics Laboratory (LESO-PB)2013
The retina is one of the best known quantum detectors with rods able to reliably respond to single photons. However, estimates on the number of photons eliciting conscious perception, based on signal detection theory, are systematically above these values ...
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus constitutes the central circadian pacemaker. The SCN receives light signals from the retina and controls peripheral circadian clocks (located in the cortex, the pineal gland, the liver, the ...
The discovery of a novel type of photoreceptor that mediates non-visual light responses in humans has sparked a growing interest in the role of lighting design on human health and wellbeing. Researchers have identified intensity, spectrum, duration/pattern ...
PURPOSE. Nonvisual light-dependent functions in humans are conveyed mainly by intrinsically photosensitive retinal ganglion cells, which express melanopsin as photopigment. We aimed to identify the effects of circadian phase and sleepiness across 24 hours ...
Association for Research in Vision and Ophthalmology2012
Neural circuits closer to the periphery tend to be organised in a topological way, i.e. stimuli which are spatially close tend to be mapped onto neighbouring processing neurons. The goal of this study is to show how motion features (optic-flow), which have ...
Ocular development is controlled by a complex network of transcription factors, cell cycle regulators, and diffusible signaling molecules. Together, these molecules regulate cell proliferation, apoptosis and specify retinal fate. In the zebrafish (Danio re ...
