Publications associées à Métabolisme des médicaments

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Yimon Aye, Jesse Poganik, Xuyu Liu, Yi Zhao, Kuan-Ting Huang

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...

eLIFE SCIENCES PUBL LTD2022

Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

Paul Joseph Dyson, Sarah Alexandra Pais Pereira

A novel automated method based on sequential injection analysis (SIA), a non-segmented flow injection technique, was developed to evaluate glutathione S-transferase P1-1 (GST P1-1) activity in the presence of organometallic complexes with putative anticanc ...

TAYLOR & FRANCIS LTD2022

Quantitative modeling of human metabolism: A call for a community effort

Vassily Hatzimanikatis, Maria Masid Barcon

Metabolism is the process by which cells and organisms obtain nutrients and energy to perform their functions. In the last years, many human diseases, including cancer, diabetes, and cardiac diseases, have been associated with altered metabolism. Understan ...

2021

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi, Anush Chiappino-Pepe

The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...

2021

Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

Rolf Gruetter, Cristina Ramona Cudalbu, Veronika Rackayová, Guillaume Donati, Dunja Simicic

Brain metabolism evolves rapidly during early post‐natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic change ...

2021

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...

NATURE RESEARCH2021

The influence of the crowding assumptions in biofilm simulations

Vassily Hatzimanikatis, Liliana Angeles Martinez

Author summary In nature, many organisms grow in crowded biofilms that protect against stressful conditions, making their control/eradication a challenge. Modeling these microbial systems is a valuable tool for studying the interactions among cells and exp ...

PUBLIC LIBRARY SCIENCE2021

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism

Vassily Hatzimanikatis, Pierre Guy Rémy Salvy

Diauxie, or the sequential consumption of carbohydrates in bacteria such as Escherichia coli, has been hypothesized to be an evolutionary strategy which allows the organism to maximize its instantaneous specific growth-giving the bacterium a competitive ad ...

NATL ACAD SCIENCES2021

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Vassily Hatzimanikatis, Georgios Fengos, Tuure Eelis Hameri

Background Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc re ...

BMC2021

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Métabolisme des médicaments

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

Quantitative modeling of human metabolism: A call for a community effort

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

The influence of the crowding assumptions in biofilm simulations

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

New and improved methods for integrated models of metabolism and gene expression

Graph Chatbot

Chattez avec Graph Search

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

Quantitative modeling of human metabolism: A call for a community effort

Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Emergence of diauxie as an optimal growth strategy under resource allocation constraints in cellular metabolism

New and improved methods for integrated models of metabolism and gene expression

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

The influence of the crowding assumptions in biofilm simulations