Publications associées à Artificial gene synthesis

New protein–protein interactions designed by a computer

Creating protein interactions through computational design is a key challenge in the fields of both basic and translational biology. An approach that uses the machine-learned fingerprints of protein-surface features was used to produce synthetic proteins t ...

2023

Taming the radical cation intermediate enabled one-step access to structurally diverse lignans

Jieping Zhu, Cédric Fung, Qiang Wang, Jia-Chen Xiang

Lignans, in spite of their structural diversity, are all biosynthetically derived from coniferyl alcohol. We report herein a divergent synthesis of lignans from biomass-derived monolignols in a short synthetic sequence. Blue LED irradiation of a dichlorome ...

2022

Catalytic Enantioselective Aminopalladation–Heck Cascade

Qian Wang, Jieping Zhu, Hua Wu, Yuping He, Jian Cao

Domino processes initiated by intramolecular nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains s ...

2021

OnePot PURE Cell-Free System

Sebastian Maerkl, Laura Sophie Grasemann, Barbora Lavickova

The defined PURE (protein synthesis using recombinant elements) transcription-translation system provides an appealing chassis for cell-free synthetic biology. Unfortunately, commercially available systems are costly, and their tunability is limited. In co ...

JOURNAL OF VISUALIZED EXPERIMENTS2021

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Sevan Mleh Habeshian, Ying Zhang

Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug discovery projects across the pharmaceutical industry. The majority of reported projects describe the discovery of rever ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Benefiting From Bicubically Down-Sampled Images for Learning Real-World Image Super-Resolution

Jean-Philippe Thiran, Thomas Yu, Seyedbehzad Bozorgtabar, Claudiu-Cristian Musat, Hazim Kemal Ekenel, Mohammad Saeed Rad

Super-resolution (SR) has traditionally been based on pairs of high-resolution images (HR) and their low-resolution (LR) counterparts obtained artificially with bicubic downsampling. However, in real-world SR, there is a large variety of realistic image de ...

2021

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Kristin Schirmer, Anze Zupanic

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...

AMER CHEMICAL SOC2020

Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Nicolai Cramer, Benoît Daniel Bertrand Audic

The creation of new chiral ligands capable of providing high stereocontrol in metal-catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis w ...

WILEY-V C H VERLAG GMBH2020

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Artificial gene synthesis

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

New protein–protein interactions designed by a computer

Taming the radical cation intermediate enabled one-step access to structurally diverse lignans

Catalytic Enantioselective Aminopalladation–Heck Cascade

OnePot PURE Cell-Free System

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Benefiting From Bicubically Down-Sampled Images for Learning Real-World Image Super-Resolution

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Graph Chatbot

Chattez avec Graph Search

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Catalytic Enantioselective Aminopalladation–Heck Cascade

Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

New protein–protein interactions designed by a computer

Taming the radical cation intermediate enabled one-step access to structurally diverse lignans

OnePot PURE Cell-Free System

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Benefiting From Bicubically Down-Sampled Images for Learning Real-World Image Super-Resolution