Publications associées à Produit naturel

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Vassily Hatzimanikatis, Jasmin Maria Hafner

Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...

NATURE RESEARCH2021

Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates

Xile Hu, Srikrishna Bera, Deyun Qian

Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates. The catalytic and enantioselective synthesis of alkyl amines from readily accessible precursors is challenging. Here we develop a nickel-catalyzed hydroalkylation metho ...

AMER CHEMICAL SOC2021

NICEpath: Finding metabolic pathways in large networks through atom-conserving substrate-product pairs

Vassily Hatzimanikatis, Jasmin Maria Hafner

Motivation: Finding biosynthetic pathways is essential for metabolic engineering of organisms to produce chemicals, biodegradation prediction of pollutants and drugs, and for the elucidation of bioproduction pathways of secondary metabolites. A key step in ...

OXFORD UNIV PRESS2021

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Qian Wang, Jieping Zhu, Bastien Delayre

The art of natural product total synthesis is closely associated with two major determinants: the development/application of novel chemical reactions and the innovation in strategic use of classic organic reactions. While purposely seeking/applying a new s ...

2021

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Yimon Aye, Amogh Kulkarni

For several years, drugs with reactive electrophilic appendages have been developed. These units typically confer prolonged residence time of the drugs on their protein targets, and may assist targeting shallow binding sites and/or improving the drug-prote ...

WILEY-V C H VERLAG GMBH2021

Alkynyl triazenes enable divergent syntheses of 2-pyrones

Kay Severin, Nicolai Cramer, Carl Thomas Bormann, Jin Fay Tan

The 2-pyrone motif occurs frequently in bioactive natural products and is appreciated as synthetic intermediates. However, only few methods allow for diversifying functional group modifications on this relevant heterocycle. The distinct properties of 1-alk ...

2021

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Pénélope Andreux, Davide D'Amico, Pamela Solange Valdés Undurraga, Anurag Singh

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

Photocatalytic Decarboxylative Coupling of Aliphatic N-hydroxyphthalimide Esters with Polyfluoroaryl Nucleophiles

Xile Hu, Lara Lavrencic, Runze Mao, Xiangli Yi

Polyfluoroarenes are an important class of compounds in medical and material chemistry. The synthesis of alkylated polyfluoroarenes remains challenging. Here we describe a decarboxylative coupling reaction of N-hydroxyphthalimide esters of aliphatic carbox ...

WILEY-V C H VERLAG GMBH2021

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Produit naturel

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates

NICEpath: Finding metabolic pathways in large networks through atom-conserving substrate-product pairs

Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Phototransformation kinetics of cyanobacterial toxins and secondary metabolites in surface waters

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Alkynyl triazenes enable divergent syntheses of 2-pyrones

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Photocatalytic Decarboxylative Coupling of Aliphatic N-hydroxyphthalimide Esters with Polyfluoroaryl Nucleophiles

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Chattez avec Graph Search

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids

Phototransformation kinetics of cyanobacterial toxins and secondary metabolites in surface waters

NICEpath: Finding metabolic pathways in large networks through atom-conserving substrate-product pairs

Alkynyl triazenes enable divergent syntheses of 2-pyrones

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Photocatalytic Decarboxylative Coupling of Aliphatic N-hydroxyphthalimide Esters with Polyfluoroaryl Nucleophiles