Concept

Endophénotype

Publications associées (26)

Cognitive markers as potential endophenotypes for schizophrenia

Schizophrenia is a heterogeneous disease strongly influenced by genetic predisposition. A large variety of candidate genes has been identified of which each gene, however, explains only a small proportion of the genetic risk. For this reason, stable marker ...

2016

Backward masking performance in patients with functional psychoses

Michael Herzog, Maya Roinishvili

In visual backward masking, a target is followed by a blank screen (ISI - Inter-stimulus-interval) and, then, a mask which deteriorates target processing. Schizophrenic patients show strong but complex processing deficits in visual masking compared to heal ...

2016

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia

Erika Myrna Borcel Novoa

Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship. Using a maternal immune activation model of schizophrenia, we tested whethe ...

Pergamon-Elsevier Science Ltd2016

Alpha7 subunit of the nicotinergic acethylcholine receptor gene (CHRNA7) and perception of coherent motion in aging

Michael Herzog

Genetic variations of the alpha7 subunit of the nicotinergic acetylcholine receptor gene (CHRNA7) are linked to cognitive deficits in aging and schizophrenia. However, little is known about associations of the CHRNA7 gene with aged-related decline in visua ...

2016

Schizophrenia patients and 22q11.2 deletion syndrome adolescents at risk express the same deviant patterns of resting state EEG microstates: A candidate endophenotype of schizophrenia

Michael Herzog, Dimitri Nestor Alice Van De Ville, Maude Schneider, Maya Roinishvili, Fikret Isik Karahanoglu

Schizophrenia is a complex psychiatric disorder and many of the factors contributing to its pathogenesis are poorly understood. In addition, identifying reliable neurophysiological markers would improve diagnosis and early identification of this disease. T ...

2015

Endophenotypes of schizophrenia: electrophysiological correlates of first episode patients

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod

Schizophrenia is a heterogeneous disorder and among other symptoms, patients have important visual impairments. Visual paradigms are therefore important tools to investigate the mechanisms of schizophrenia. During the last period of the NCCR, we have chara ...

2015

Visual backward masking deficits in schizotypy

Michael Herzog, Christine Mohr, Ophélie Gladys Favrod

In visual backward masking, a briefly presented target is followed by a mask, which impairs target discrimination. Backward masking is strongly impaired in schizophrenic patients and their unaffected relatives. We found that masking deficits correlated wel ...

2013

Cognitive disorganisation and Sex affect visual backward masking: data from patients with schizophrenia, non-affected relatives and healthy controls

Michael Herzog, Christine Mohr, Maya Roinishvili, Guillaume Sierro

Endophenotypes (i.e. stable and heritable markers of the illness) are one of the promising tools to understand the pathological mechanisms underlying schizophrenia. We recently showed that deficits in visual backward masking (VBM) meet the criteria for an ...

2013

Visual backward masking deficits are specific to female observers scoring high on cognitive disorganisation

Michael Herzog, Christine Mohr, Guillaume Sierro

Visual backward masking (VBM) deficits are a potential endophenotype of schizophrenia. VBM deficits were found in schizophrenic patients, in their unaffected relatives, and in healthy students scoring high in "cognitive disorganisation" (CD; Cappe et al., ...

2013

Schizophrenia and visual backward masking: a general deficit of target enhancement

Michael Herzog, Maya Roinishvili

The obvious symptoms of schizophrenia are of cognitive and psychopathological nature. However, schizophrenia affects also visual processing which becomes particularly evident when stimuli are presented for short durations and are followed by a masking stim ...

Frontiers Research Foundation2013

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