Concept

Effet secondaire (médecine)

Publications associées (44)

Path integral evaluation of the equilibrium isotope effect in [1,5] sigmatropic hydrogen shift reactions

The path integral methodology for computation of the equilibrium isotope effect is described and applied to three [1,5] sigmatropic hydrogen shift reactions. An efficient estimator for the derivative of the free energy is used, which shortens the computati ...

2009

KP1019, a new redox-active anticancer agent - preclinical development and results of a clinical phase I study in tumor patients

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

A review. The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clin. trials. In this review, which is an update of a paper from 2006, the exptl. evidence for the ...

2008

Immobilization of rapeseed press-cake in an alginate matrix for the sorption of atrazine

Urs von Stockar, Ian William Marison, Véronique Breguet, Julien Boucher

Due to residual oil retained within it, rapeseed press-cake has been shown to be effective for the removal of atrazine from water through an absorption mechanism. However, it is difficult to put this into practice due to the hygroscopic nature of the press ...

2008

Development of new anticancer agents based on [alpha]-mannosidase inhibition

Hélène Fiaux

Enzymes that are involved in the synthesis and processing of oligosaccharides, such as glycosidases, are important catalysts for the specific assembly of oligosaccharide structures on proteins. Design and preparation of selective inhibitors of these enzyme ...

EPFL2007

Microstructure of (Na0.5La0.5)MoO4 crystals coactivated with cerium and erbium ions

Elena Suvorova Buffat

Crystals with the scheelite structure have been grown by the Czochralski technique from a melt of composition (Na0.5La0.345Ce0.15Er0.005) MoO4 (NLM: Ce, Er) and have been characterized by scanning and transmission electron microscopy and x-ray microanalysi ...

2007

Simulation of CO2 concentrations, temperature, and stratification in Lake Nyos for different degassing scenarios

Alfred Johny Wüest, Martin Schmid

[ 1] A large gas cloud erupted unexpectedly in 1986 from Lake Nyos, the larger of the two Cameroonian "Killer Lakes,'' with devastating consequences. Regular monitoring subsequently revealed that the deep water of the lake was gradually recharged with CO2. ...

Amer Geophysical Union2006

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue ...

EPFL2005

Huntington's disease modeling and treatment

Diana Zala

Huntington's disease (HD) is a mid-life-onset neurodegenerative disorder characterized by involuntary movements, personality changes and dementia. It progresses to death within 10-20 years after onset. There is currently no cure to treat this fatal disease ...

EPFL2005

Phasing in the presence of severe-site specific radiation damage through dose-dependent modelling of heavy atoms

The case of a brominated RNA crystal structure determination in which standard three-wavelength MAD phasing was unsuccessful because of fast X-ray-induced debromination was reinvestigated [Ennifar et al. ( 2002), Acta Cryst. D58, 1262 - 1268]. It was found ...

2004

Synthesis and ring-opening (Co)polymerization of L-lysine N-carboxyanhydrides containing labile side-chain protective groups

Harm-Anton Klok

This contribution describes the synthesis and ring-opening (co)polymerization of several L-lysine N-carboxyanhydrides (NCAs) that contain labile protective groups at the ε-NH2 position. Four of the following L-lysine NCAs were investigated: Nε-trifluoroace ...

2003

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