Concept

In vitro

Publications associées (206)

Interactions of Tris with rutile surfaces and consequences for in vitro bioactivity testing

Tris(hydroxymethyl)aminomethane (Tris) has been used as the buffer in bioactivity testing for over two decades and has become a standard choice for the scientific community. While it is believed to be non-interacting, the extent of its interactions with ti ...

Amsterdam2021

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Harm-Anton Klok, Olivier Burri, Arne Seitz, Romain Guiet, Maxime Ayer

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

2021

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation

Sandrine Gerber, Céline Marie Anne Journot, Laura Camille Louise Nicolle

There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-solubl ...

2021

Insights gained from a comprehensive all-against-all transcription factor binding motif benchmarking study

Giovanna Ambrosini, Philipp Bucher, Romain Fernand Pietro Groux

BackgroundPositional weight matrix (PWM) is a de facto standard model to describe transcription factor (TF) DNA binding specificities. PWMs inferred from in vivo or in vitro data are stored in many databases and used in a plethora of biological application ...

2020

Extending the Concept of Predicting Fish Acute Toxicity In Vitro to the Intestinal Cell Line RTgutGC

Kristin Schirmer, Hannah Inka Schug, Jenny Maner

Testing chemicals for fish acute toxicity is a legal requirement in many countries as part of environmental risk assessment. To reduce the number of fish used, substantial efforts have been focused on alternative approaches. Prominently, the cell viability ...

SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH2020

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

NATL ACAD SCIENCES2020

Synthesis of bioactive material by sol-gel process utilizing polymorphic calcium carbonate precipitate and their direct and indirect in-vitro cytotoxicity analysis

Edgard Gnansounou, Manish Kumar

To mitigate the rising level of CO2, biological method of CO2 sequestration is one of the effective methods. Chemolithotrophic microbes are able to fix atmospheric CO2 and precipitated polymorphic minerals like calcite, vaterite and aragonite. Based on thi ...

ELSEVIER2020

Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society

Olaia Maria Naveiras Torres-Quiroga, Josefine Catharina Pedersen Tratwal

The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation, chemotherapy ...

2020

Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

Cristina Ramona Cudalbu, Bernard Lanz

With a 40-year history of use for in vivo studies, the terminology used to describe the methodology and results of magnetic resonance spectroscopy (MRS) has grown substantially and is not consistent in many aspects. Given the platform offered by this speci ...

WILEY2020

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Matthias Lütolf, Nikolche Gjorevski

Intestinal organoids are useful in vitro models for basic and translational studies aimed at understanding and treating disease. However, their routine culture relies on animal-derived matrices that limit translation to clinical applications. In fact, ther ...

WILEY-V C H VERLAG GMBH2020

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