Publications associées à Motoneurone

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Bernard Schneider, Nicholas David James

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digesti ...

Society for Neuroscience2014

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

Michele Giugliano

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...

Public Library Science2014

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Johan Auwerx, Pénélope Andreux

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that causes death of motor neurons. ALS patients and mouse models of familial ALS display organismal level metabolic dysfunction, which includes increased energy expenditure despite ...

Oxford University Press2014

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

Patrick Aebischer, Christopher Towne

Selective neuronal loss is the hallmark of neurodegenerative diseases. In patients with amyotrophic lateral sclerosis (ALS), most motor neurons die but those innervating extraocular, pelvic sphincter, and slow limb muscles exhibit selective resistance. We ...

Elsevier2014

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Grégoire Courtine, Isabel Laura Vollenweider

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...

Elsevier2014

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Hilal Lashuel, Nadine Aït Bouziad, Mohamed Bilal Fares, Martial Mbefo Kamdem, Ana Jovicic

A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy (MSA). In this study, we explored the impact of this novel mutation on ...

Oxford University Press2014

The control of complex finger movements by directional information flow between mesial frontocentral areas and the primary motor cortex

Friedhelm Christoph Hummel

Complex movements require the interplay of local activation and interareal communication of sensorimotor brain regions. This is reflected in a decrease of task-related spectral power over the sensorimotor cortices and an increase in functional connectivity ...

Wiley-Blackwell2014

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Henry Markram, Julie Meystre, Maurizio Ferdinando Pezzoli, Johannes Le Coutre, Susana Camacho Romero, Sara Lillian Gonzalez Andino

Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores how different AIS modulate neural response in layer 5 pyramidal neurons of S1 ne ...

Nature Publishing Group2014

Distributor of neurons in a neocortical column

Henry Markram, Felix Schürmann, Georges Khazen, Martin Telefont

Computer-implemented methods, software, and systems for determining a distribution of neuronal cells across a portion of a brain are described. One computer-implemented method for determining a target distribution of one or more neuronal cells across a por ...

2014

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Motoneurone

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Differential behavioral and physiological effects of anodal transcranial direct current stimulation in healthy adults of younger and older age

The control of complex finger movements by directional information flow between mesial frontocentral areas and the primary motor cortex

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Distributor of neurons in a neocortical column

Graph Chatbot

Chattez avec Graph Search

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Differential behavioral and physiological effects of anodal transcranial direct current stimulation in healthy adults of younger and older age

The control of complex finger movements by directional information flow between mesial frontocentral areas and the primary motor cortex

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Distributor of neurons in a neocortical column