Concept
Minimum viable population
Publications associées (56)
Impact of population size on early adaptation in rugged fitness landscapes
Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean
Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...
ROYAL SOC2023Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity
Anne-Florence Raphaëlle Bitbol
The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that i ...
National Academy of Sciences2022On the relation between transversal and longitudinal scaling in cities
João Vitor Meirelles de Miranda
Does the scaling relationship between population sizes of cities with urban metrics like economic output and infrastructure (transversal scaling) mirror the evolution of individual cities in time (longitudinal scaling)? The answer to this question has impo ...
2020Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment
Anne-Florence Raphaëlle Bitbol, Loïc Marrec
We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...
2020Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion
Marion Leleu, Ludovica Vanzan, Flavia Marzetta, Ioannis Xenarios
Expanded CAG/CTG repeats underlie 13 neurological disorders, including myotonic dystrophy type 1 (DM1) and Huntington's disease (HD). Upon expansion, disease loci acquire heterochromatic characteristics, which may provoke changes to chromatin conformation ...
2020Nash and Wardrop Equilibria in Aggregative Games With Coupling Constraints
Maryam Kamgarpour, John Lygeros
We consider the framework of aggregative games, in which the cost function of each agent depends on his own strategy and on the average population strategy. As first contribution, we investigate the relations between the concepts of Nash and Wardrop equili ...
2019