Concept

Protein microarray

Publications associées (139)

Semisynthetic Fluorescent Sensor Proteins Based on Self-Labeling Protein Tags

Genetically encoded fluorescent sensor proteins offer the possibility to probe the concentration of key metabolites in living cells. The approaches currently used to generate such fluorescent sensor proteins lack generality, as they require a protein that ...

EPFL2011

An extracellular matrix protein microarray to study endothelial to mesenchymal transformation in mitral valve endothelial cells

Blaise Calpe

In the developing heart, a subset of endothelial cells (ECs) undergo a process of endothelial to mesenchymal transformation (EMT) that leads to the remodeling of the cardiac cushions and the formation of the cardiac valves. Understanding how microenvironme ...

2011

Rgtsp: a generalized top scoring pairs package for class prediction

Mauro Delorenzi, Vlad Popovici

A top scoring pair (TSP) classifier consists of a pair of variables whose relative ordering can be used for accurately predicting the class label of a sample. This classification rule has the advantage of being easily interpretable and more robust against ...

Oxford University Press2011

Microfluidic device for analysis of protein biomarkers using magnetic bead surface coverage detection

Martinus Gijs, Hüseyin Cumhur Tekin, Cynthia Scherz

We present a microfluidic device for on-chip analysis of low-concentration protein biomarkers. A new detection method, based on the magnetic capture of proteins via superparamagnetic beads and counting the surface coverage of the latter is presented. The p ...

2011

Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains

Felix Naef, Christian Antonio Pozzorini, Jonathan Bieler

Segmentation of the Drosophila melanogaster embryo results from the dynamic establishment of spatial mRNA and protein patterns. Here, we exploit recent temporal mRNA and protein expression measurements on the full surface of the blastoderm to calibrate a d ...

2011

Microchannel-guided capture antibody patterning on beads for multiple protein detection arrays

Martinus Gijs, Hüseyin Cumhur Tekin, Venkataragavalu Sivagnanam, Sébastien Vaneberg

We present the rapid fabrication of custom protein micro-arrays, in less than 35 minutes, on the surface of immobilized beads using microchannel-guided flows driven by a single syringe pump. The commercially available beads provide robust micro-array surfa ...

2011

Design review of a compact and low cost elementary radiating cell for satellite broadcasting automotive receiving arrays

Juan Ramon Mosig, Stefano Vaccaro, Roberto Torres Sánchez

This communication presents a review of the developments carried out towards the electromagnetic modeling, design and practical implementation of the basic building block of a planar antenna for the reception of Ku-band satellite broadcasting services from ...

2011

A Time-Gated 128x128 CMOS SPAD Array for on-Chip Fluorescence Detection

Edoardo Charbon

An all-digital, time-gated 128x128 CMOS image sensor for on-chip fluorescence detection is presented. The sensor pixel consists of a single-photon avalanche diode (SPAD), time gating circuitry and a 1bit memory. The sensor allows on-chip fluorescence detec ...

2011

Protein Microarrays Based on Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

Harm-Anton Klok, Raphaël Barbey, Markus Ehrat

Polymer brushes represent an interesting platform for the development of high-capacity protein binding surfaces. Whereas the protein binding properties of polymer brushes have been investigated before, this manuscript evaluates the feasibility of poly(glyc ...

2010

Polymer Brushes as Substrates for Microarray Applications

Raphaël Barbey

The development of innovative bioanalytical technologies that enable the discovery of new therapeutics or the creation of systems for rapid, accurate and parallel analyses has gained an extraordinary interest in the biomedical sector in the last 10-15 year ...

EPFL2010

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