Publications associées à Perfusion intraveineuse

Lithium-Niobate-Based Frequency-Agile Integrated Lasers

Tobias Kippenberg, Rui Ning Wang, Anat Siddharth, Mikhail Churaev, Viacheslav Snigirev, Grigorii Likhachev, Junqiu Liu, Guanhao Huang

We demonstrate narrow- linewidth ultrafast tunable integrated lasers based on heterogeneously integrated thin-film lithium niobate on ultra-low loss silicon nitride integrated photonic circuits. Using self-injection locking of a hybrid microresonator, we a ...

IEEE2022

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

2023

Dissecting the role of the asparagine synthesis in acute liver injury

Yu Sun

Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...

EPFL2022

Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum With Machine Learning

Sandro Carrara, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Simone Aiassa

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesi ...

2021

Magnetization-prepared 2 Rapid Gradient-Echo MRI for B-1 Insensitive 3D T1 Mapping of Hip Cartilage: An Experimental and Clinical Validation

Tobias Kober

Background: Often used for T1 mapping of hip cartilage, three-dimensional (3D) dual-flip-angle (DFA) techniques are highly sensitive to flip angle variations related to B-1 inhomogeneities. The authors hypothesized that 3D magnetization-prepared 2 rapid gr ...

RADIOLOGICAL SOC NORTH AMERICA2021

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

Johan Auwerx

Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...

2020

Detection of myocardial medium‐chain fatty acid oxidation and tricarboxylic acid cycle activity with hyperpolarized [1– 13 C]octanoate

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara

Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The magnetic resonance signal enhancement provided by spin hyperpolarizati ...

2020

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Johan Auwerx, Norman Lionel Moullan, Lei Chen

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Dynamics of Soliton Microcomb Self-Injection Locking in a Silicon Nitride Microresonator

Tobias Kippenberg, Junqiu Liu, Andrey Voloshin

We demonstrate a chip-scale 30 GHz single soliton microcomb based on DFB laser locked to a Si3N4 microresonator. We propose novel theoretical and experimental approaches to explain dynamics of self-injection locking, modified by Kerr nonlinearity. (c) 2020 ...

IEEE2020

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018