Concept

Réaction de Wittig

Publications associées (61)

Chiral Cyclopentadienyl Ruthenium (II) Complexes

Cyclopentadienyl ruthenium(II) complexes are an important class of homogenous catalysts. They engage in a multitude of different transformations, for example cycloisomerizations. Due to a lack of suitable chiral cyclopentadienyl ligands, no efficient enant ...

EPFL2017

Copper-Catalyzed Three-Component Carboazidation of Alkenes with Acetonitrile and Sodium Azide

Qian Wang, Jieping Zhu, Ala Bunescu, Minh Tu Ha

A copper-catalyzed three-component reaction of alkenes, acetonitrile, and sodium azide afforded gamma-azido alkyl nitriles by formation of one C(sp3)-C(sp3) bond and one C(sp3)-N bond. The transformation allows concomitant introduction of two highly versat ...

Wiley-Blackwell2017

Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile

Qian Wang, Jieping Zhu, Martina Spallarossa

The reaction of isocyanomethylenetriphenylphosphorane, generated in situ from the corresponding phosphonium salt, with a diverse set of aldehydes afforded vinyl isocyanides in good to high yields. Excellent E-selectivity was observed for aliphatic aldehyde ...

American Chemical Society2016

Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B

Jieping Zhu

An enantioselective synthesis of a putative lipiarmycin aglycon was accomplished and features: 1) Brown’s enantioselective alkoxyallylboration and allylation of aldehydes, 2) chain elongation by iterative Horner–Wadsworth– Emmons olefination, 3) Evans aldo ...

Wiley-Blackwell2015

Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles

Qian Wang, Jieping Zhu, Ala Bunescu

A copper-catalyzed oxyalkylation of allylic alcohols using nonactivated alkyl nitriles as reaction partners was developed. A sequence involving generation of an alkyl nitrile radical followed by its addition to a double bond and a copper-mediated formation ...

Amer Chemical Soc2015

Aromatic Homologation by Non- Chelate- Assisted RhIII- Catalyzed C -H Functionalization of Arenes with Alkynes

Nicolai Cramer, Van Manh Pham

Larger condensed arenes are of interest owing to their electro- and photochemical properties. An efficient synthesis is the catalyzed aromatic annulation of a smaller arene with two alkyne molecules. Besides difunctionalized starting materials, directed CH ...

Wiley-V C H Verlag Gmbh2014

Intensification of slow reversible chemical transformation: carboxylation of resorcinol as a case study

Lioubov Kiwi, Charline Berguerand, Anne-Laure Dessimoz

Conjugated kinetic and thermodynamic modeling is suggested as a suitable approach to identify a novel process window (NPW) for the intensification of slow reversible reactions. The aqueous Kolbe-Schmitt synthesis of beta-resorcylic acid is taken as a model ...

De Gruyter2013

Arginine-Specific Modification of Proteins with Polyethylene Glycol

Harm-Anton Klok, Marc Gauthier

In this study, the residue-selective modification of proteins with polymers at arginine residues is reported. The difficulty in modifying arginine residues lies in the fact that they are less reactive than lysine residues. Consequently, typical chemo-selec ...

2011

First-Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity

Nicola Marzari

We present here a computational study of reactions at a model complex of the SyrB2 enzyme active site. SyrB2, which chlorinates L-threonine in the syringomycin biosynthetic pathway, belongs to a recently discovered class of alpha-ketoglutarate (alpha KG), ...

2009

Direct observation of reaction intermediates for a well defined heterogeneous alkene metathesis catalyst

Frédéric Blanc, David Lyndon Emsley, Rajkumar Singh

Grafting of [W( NAr)(=CHtBu)(2,5-Me2NC4H2)(2)] on a silica partially clehydroxylated at 700 degrees C (SiO2-(700)) generates the corresponding monosiloxy complex [( SiO)W( NAr)(=CHtBu)(2,5-Me2NC4H2)] as the major species (approximate to 90%) along with [( ...

NATL ACAD SCIENCES2008

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