Concept
Leucémie
Publications associées (67)
Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease
Acute leukemia has a high mortality rate of approximately 50%, and current methods are not effective in predicting disease progression and relapse. To improve our understanding of hematopoiesis and develop new markers for predicting disease relapse in dead ...
EPFL2023Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells
Cyrus Kazemiraad, Saeed Mohammadi
Vimentin is a main type 3 intermediate filament protein. It seems that abnormal expression of vimentin is contributed to the appearance of the aggressive feature of cancer cells. So that it has been reported that malignancy and epithelial-mesenchymal trans ...
SPRINGER2023Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...
EPFL2023Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
Freddy Radtke, Ute Koch, Nadine Fournier, Marianne Nkosi, Christelle Dubey, Mateusz Waldemar Antoszewski, Tara Kimberly Sugrue, Giovanni Ciriello
NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape du ...
AMER SOC HEMATOLOGY2022Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia
Freddy Radtke, Ute Koch, Nadine Fournier, Jessica Sordet, Marianne Nkosi, Delphine Maude Tardivon, Mateusz Waldemar Antoszewski
NOTCH1 gain-of-function mutations are recurrent in B-cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The specific role of NOTCH1 in the development and progressio ...
AMER SOC HEMATOLOGY2021Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors
Notch1 receptor signaling is essential for T cell fate specification and physiological thymic T lymphocyte development. Its dysregulation and oncogenic activation are detected in almost 80% of pediatric patients suffering from T cell acute lymphoblastic le ...
EPFL2021Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)
Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome-positive (Ph+) leukemia. With the exception of ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit the common "gatekeeper" mutation T315I ...
SPRINGER2021Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression
Chronic lymphocytic leukemia (CLL) is a B cell malignancy and represents the most common leukemia in adults within the Western world. This disease mainly affects the elderly, with a median age of diagnosis over 70. The disease course is highly variable amo ...
EPFL2020Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia
Filipe Amândio Brandão Sanches Vong Martins
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia ...
SPRINGER2020In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro
Matthias Lütolf, Aline Roch, Mukul Girotra, Vincent Trachsel
Hematopoietic stem cells (HSCs) are responsible for life-long production of all mature blood cells. Under homeostasis, HSCs in their native bone marrow niches are believed to undergo asymmetric cell divisions (ACDs), with one daughter cell maintaining HSC ...
MDPI2020