Concept

Enrichissement environnemental

Publications associées (16)

A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model

Disruption of brain development early in life may underlie the neurobiology behind schizophre-nia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizoph ...

2023

Compressed sensing (CS) MP2RAGE versus standard MPRAGE: A of derived brain volume measurements

Tobias Kober, Tom Hilbert, Gian Franco Piredda

Purpose: T1 Magnetization Prepared Two Rapid Acquisition Gradient Echo (MP2RAGE) with compress sensing (CS) has been proposed as an improvement of the standard MPRAGE sequence with multiple advantages including reduced acquisition time needed to provide a ...

ELSEVIER SCI LTD2022

Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas

Carl Petersen, Sylvain Crochet, Romain Guiet, Vahid Esmaeili, Yanqi Liu, Georgios Foustoukos, Keita Tamura, Anastasiia Oryshchuk, Reza Asri

Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in ...

2022

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabili ...

2017

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

Silvestro Micera, Stefano Lai

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective str ...

Frontiers Media Sa2017

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Jean-Marie Petit, Pascal Jourdain, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Henry Markram, Felix Schürmann, Yun Wang, Imad Riachi

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Natl Acad Sciences2012

A Role For Adult Neurogenesis In Dentate Synaptic Plasticity Deficits And Memory Impairment In Down Syndrome

In the mammalian dentate gyrus (DG) neurogenesis continues throughout life. Accumulating evidence suggests a unique contribution of adult-generated neurons in DG synaptic plasticity and hippocampal-mediated learning and memory functions. However, the preci ...

2012

A role for adult neurogenesis in dentate synaptic plasticity deficits and memory impairment in Down syndrome

Diego Ghezzi

The hippocampal dentate gyrus (DG) is one of the two sites where neurogenesis continues throughout life in the mammalian brain. Accumulating evidence suggests a unique contribution of adult-generated dentate neurons in hippocampal synaptic plasticity and h ...

2012

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation

Ozgün Gökce, Heike Runne

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is believed to be an important regulator of striatal neuron survival, differentiation, and plasticity. Moreover, reduction of BDNF delivery to the striatum has been implicated in the pathophysiology of H ...

Public Library of Science2009

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search