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Publications associées (691)

Physiological adaptation of Desulfitobacterium hafniense strain TCE1 to tetrachloroethene respiration

Christof Holliger, Julien Maillard, Laure Prat

Desulfitobacterium spp. are ubiquitous organisms with a broad metabolic versatility and some isolates have the ability to use tetrachloroethene (PCE) as terminal electron acceptor. In order to identify proteins involved in this organohalide respiration pro ...

American Society for Microbiology2011

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Heinrich Hofmann

Background: Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal ...

2011

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez, Jiujiu Yu

The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...

2011

The Golgi apparatus: an organelle with multiple complex functions

Giovanni D'Angelo

Remarkable advances have been made during the last few decades in defining the organizational principles of the secretory pathway. The Golgi complex in particular has attracted special attention due to its central position in the pathway, as well as for it ...

2011

From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh

Many important problems in cell biology arise from the dense nonlinear interactions between functional modules. The importance of mathematical modelling and computer simulation in understanding cellular processes is now indisputable and widely appreciated. ...

Wiley-Blackwell2011

Pore-forming toxins induce multiple cellular responses promoting survival

Françoise Gisou van der Goot Grunberg, Mirko Bischofberger, Sylvia Ho, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since thi ...

Wiley-Blackwell2011

The response of Desulfotomaculum reducens MI-1 to U(VI) exposure: a transcriptomic study

Rizlan Bernier-Latmani, Elena Cristina Dalla Vecchia

Desulfotomaculum reducens is the first Gram-positive sulfate- and metal-reducing bacterium for which the transcriptomic response to uranium exposure has been evaluated. The genes upregulated during fermentative growth in the presence of U(VI) as compared t ...

Taylor & Francis2011

E2F transcription factor-1 regulates oxidative metabolism

Johan Auwerx

Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic ...

2011

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hélène Danielle Perreten Lambert

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011

Semisynthesis of fluorescent metabolite sensors on cell surfaces

Horst Vogel, Kai Johnsson, Luc Reymond, Rudolf Griss, Joachim Piguet, Matthias Albert Brun, Kui Thong Tan, Ruud Peters

Progress in understanding signal transduction and metabolic pathways is hampered by a shortage of suitable sensors for tracking metabolites, second messengers, and neurotransmitters in living cells. Here we introduce a class of rationally designed semisynt ...

2011

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