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Publications associées (691)

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes

Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Jean-Yves Chatton

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...

2011

Photocatalytic discoloration of aqueous malachite green solutions by UV-illuminated TiO2 nanoparticles under air and nitrogen atmospheres: effects of counter-ions and pH

César Pulgarin, Christophe Roussel

Under air atmosphere, the photocatalytic discoloration of malachite green (MG) aqueous solutions (a triphenylmethane dye) in the presence of TiO2 and UV light followed an oxidative pathway, involving an N-demethylation process evidenced by a blue shifting ...

2011

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

Pierre Magistretti, Igor Allaman

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes a type of glial cell have emerged as active pla ...

2011

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Pierre Magistretti, Igor Allaman, Thierry Laroche, Jean-Marie Petit, Jiangyan Yang

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011

Highly Sensitive Carbon Nanotube-Based Sensing for Lactate and Glucose Monitoring in Cell Culture

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Giovanna Del Vecchio

Monitoring of metabolic compounds in cell cultures can provide real-time information of cell line status. This is particularly important in those lines not fully known, as the case of embryonic and mesenchymal cells. On the other hand, such approach can pa ...

Institute of Electrical and Electronics Engineers2011

Compositions and use of sulfasalazine

Kai Johnsson, Christopher Chidley

The invention relates to compositions comprising sulfasalazine or sulfapyridine and products of a biosynthetic pathway that requires tetrahydrobiopterin. Such compositions are useful for the treatment of inflammatory bowel diseases or rheumatoid arthritis, ...

2011

Covalent cell surface functionalization of human fetal osteoblasts for tissue engineering

Sandrine Gerber, Corinne Scaletta, Davide Städler, Aurélien Godinat, Françoise Borcard

The chemical functionalization of cell-surface proteins of human primary fetal bone cells with hydrophilic bioorthogonal intermediates was investigated. Toward this goal, chemical pathways were developed for click reaction-mediated coupling of alkyne deriv ...

2011

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto

SIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether deletion of PARP-2, an alternative NAD+-consuming enzyme, impacts on NAD+ bioavailability and SIRT1 acti ...

Elsevier2011

Hydrophilic Nanogels

Catherine Ann Schütz

Hydrophilic nanocarriers, formed by electrostatic interaction between their oppositely charged components, are recognized as nanomaterials with an enormous potential as vectors in biomedical and pharmaceutical applications. However, comprehensive informati ...

EPFL2011

Assessing the cellular uptake pathway for poly-Lysine analogues using triplet lifetime imaging

Dimitri Nestor Alice Van De Ville, Theo Lasser, Harm-Anton Klok, Iwan Märki, Zuzana Kadlecova

Research on synthetic delivery vectors is of major interest for cell imaging and manipulation, as they allow an efficient transfer of nucleic acids, therapeutic proteins or small drugs into the cells. We have developed a library of L-lysine analogues that ...

2011

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