Brain simulation | EPFL Graph Search

Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. Various simulations from around the world have been fully or partially released as open source software, such as C. elegans, and the Blue Brain Project Showcase. In 2013 the Human Brain Project, which has utilized techniques used by the Blue Brain Project and built upon them, created a Brain Simulation Platform (BSP), an internet-accessible collaborative platform designed for the simulation of brain models. Methods Modelling a brain (or brain subsystem) involves modelling neurons' electrical and bulk chemical properties (e.g. extracellular serotonin gradients). A model of the neural connectome of the target organism is also required. The connectome is extremely complex, and its detailed wiring is not ye

Technology Strategy in Dynamic Environments: A Computational Analysis of the Automation of Routines, the Organization of AI, and the Evaluation of Technology Risk

In this dissertation, I develop theory and evidence to argue that new technologies are central to how firms organize to create and capture value. I use computational methods such as reinforcement learning and probabilistic topic modeling to investigate three topics: the automation of routines, the organization of artificial intelligence (AI), and the evaluation of technology risk. Overall, I argue that new technologies are not a panacea for the firm but require deliberate strategic planning to manage the potential downsides of myopic automation, AI interdependencies, and the disclosure of technology risks.In the first essay, I argue that while automation can increase productivity by reducing the costs of coordinating individuals, the automation of routines can also incur an indirect opportunity cost due to slow adaptation to environmental change. I develop a reinforcement learning simulation to model the impact of automation on the returns from the division of labor in dynamic environments and to show how automation incurs opportunity costs through lost learning and slow adaptation. Moreover, automation can be suboptimal when it brings about myopic behavior, i.e. high returns from the division of labor in the short term, but negative returns in the long term. Given the simulation results, I argue that firms need dynamic routines to simultaneously balance learning and automation. I open-source the simulation platform as OrgSim-RL on GitHub.In the second essay, I argue that a data-driven culture - what I define as a Data Clan - can help to coordinate complex interdependencies between AI components within a firm. I analyze in-depth semi-structured interview data with a hierarchical stochastic block model (hSBM) and hand-coding to find that managers focus primarily on building a strong culture and establishing high-quality data assets when allocating resources to AI initiatives. Given the results, I inductively develop implications for theory and argue that the emergence of a Data Clan can be a governance mechanism to reduce coordination frictions and build a competitive advantage in the age of AI.In the third essay, I argue that investors require a higher initial return to take on more technology risk disclosure during an IPO. I quantify the magnitude of disclosed risk and the risk disclosure topics based on a latent Dirichlet allocation (LDA) topic model of IPO prospectus text and find a return-for-risk association between text-based technology risk disclosure and underpricing. The study also finds evidence that owning granted patents is associated with a lower return-for-risk association, suggesting that intellectual property allows the disclosure of risk without losing the competitive advantage. I open-source the code for quantifying risk disclosure as RiskyData-LDA on GitHub.In summary, this dissertation develops theory and finds evidence across three essays to argue that leveraging new technologies requires deliberate strategic planning to manage potential downsides of new technologies, such as the opportunity costs of automation, coordination costs, and costs associated with raising capital. The results suggest three mitigating solutions: dynamic routines to balance learning and automation, a Data Clan to improve coordination, and disclosure through patents to reduce underpricing.

EPFL2022

CoreNEURON : An Optimized Compute Engine for the NEURON Simulator

Jérémy Pierre Benoit Fouriaux, Michael Lee Hines, James Gonzalo King, Pramod Shivaji Kumbhar, Aleksandr Ovcharenko, Felix Schürmann

The NEURON simulator has been developed over the past three decades and is widely used by neuroscientists to model the electrical activity of neuronal networks. Large network simulation projects using NEURON have supercomputer allocations that individually measure in the millions of core hours. Supercomputer centers are transitioning to next generation architectures and the work accomplished per core hour for these simulations could be improved by an order of magnitude if NEURON was able to better utilize those new hardware capabilities. In order to adapt NEURON to evolving computer architectures, the compute engine of the NEURON simulator has been extracted and has been optimized as a library called CoreNEURON. This paper presents the design, implementation, and optimizations of CoreNEURON. We describe how CoreNEURON can be used as a library with NEURON and then compare performance of different network models on multiple architectures including IBM BlueGene/Q, Intel Skylake, Intel MIC and NVIDIA GPU. We show how CoreNEURON can simulate existing NEURON network models with 4-7x less memory usage and 2-7x less execution time while maintaining binary result compatibility with NEURON.

2019

Technology Strategy in Dynamic Environments: A Computational Analysis of the Automation of Routines, the Organization of AI, and the Evaluation of Technology Risk

EPFL2022