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This paper introduces the connection-graph-stability method and uses it to establish a new lower bound on the algebraic connectivity of graphs (the second smallest eigenvalue of the Laplacian matrix of the graph) that is sharper than the previously publish ...
In this thesis we investigate different ways of approximating the solution of the chemical master equation (CME). The CME is a system of differential equations that models the stochastic transient behaviour of biochemical reaction networks. It does so by d ...
Monitoring traffic events in computer network has become a critical task for operators to maintain an accurate view of a network's condition, to detect emerging security threats, and to safeguard the availability of resources. Conditions detrimental to a n ...
Epithelial cell migration requires coordination of two actin modules at the leading edge: one in the lamellipodium and one in the lamella. How the two modules connect mechanistically to regulate directed edge motion is not understood. Using live-cell imagi ...
Summary: Among classical methods for module detection, SpaCEM3 provides ad hoc algorithms that were shown to be particularly well adapted to specific features of biological data: high-dimensionality, interactions between components (genes) and integrated t ...
The functional properties of resting brain activity are poorly understood, but have generally been related to self-monitoring and introspective processes. Here we investigated how emotionally positive and negative information differentially influenced subs ...
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectab ...
The experimental determination of transcriptional regulatory networks in the laboratory remains difficult and time-consuming, while computational methods to infer these networks provide only modest accuracy. The latter can be attributed in part to the limi ...
Precise information about kinetic properties of enzymes within a biochemical network is a necessary ingredient of any successful metabolic engineering design. Such information inevitably involves uncertainty due to changes in cellular and process parameter ...
We present a novel conceptual framework and methodology for studying virtual water trade. We utilize complex network theory to analyze the structure of the global virtual water trade associated with the international food trade. In the global virtual water ...