Concept

Métabolite secondaire

Publications associées (88)

Reconstruction of biological pathways and metabolic networks from in silico labeled metabolites

Vassily Hatzimanikatis, Jasmin Maria Hafner, Noushin Hadadi, Keng Cher Soh

Reaction atom mappings track the positional changes of all of the atoms between the substrates and the products as they undergo the biochemical transformation. However, information on atom transitions in the context of metabolic pathways is not widely avai ...

Wiley-V C H Verlag Gmbh2017

Total Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

Christoph Heinz

The natural product fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It displays inhibitory activity against TNF-Î±-induced activation of NFÎºB, an important transcription factor and a potential t ...

EPFL2016

Total Synthesis of Fijiolide A

Nicolai Cramer, Christoph Heinz

Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It was found to significantly reduce the TNF-alpha induced activity of the transcription factor NF kappa B, which is considered a promising target ...

Schweizerische Chemische Gesellschaft2016

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Aleksandra Konovalova

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

Nicolai Cramer, Christoph Heinz

Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete and displays inhibitory activity against TNF-α-induced activation of NFκB, an important transcription factor and a potential target for the treatment of different cancers and ...

American Chemical Society2015

Full System for Translational Studies of Personalized Medicine with Free-Moving Mice (invited)

Giovanni De Micheli, Sandro Carrara, Catherine Dehollain, Francesca Stradolini, Cristina Boero, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Enver Gürhan Kilinç, Grégoire Casimir Joseph Surrel, Stefano Riario

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, two other sensors, a coil to receive power, and an ...

2015

Wikipedia Chemical Structure Explorer: substructure and similarity searching of molecules from Wikipedia

Luc Patiny, Michaël Giuseppe Zasso

Background: Wikipedia, the world's largest and most popular encyclopedia is an indispensable source of chemistry information. It contains among others also entries for over 15,000 chemicals including metabolites, drugs, agrochemicals and industrial chemica ...

Biomed Central Ltd2015

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Stewart Cole, Ruben Hartkoorn

To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening of a library of 594 hit compounds uncovered two leads that were active against M. tuberculosi ...

Elsevier2015

Oriented MFI membranes by gel-less secondary growth of sub-100 nm MFI-nanosheet seed layers

Kumar Varoon Agrawal, Han Zhang

A zeolite membrane fabrication process combining 2D-zeolite nanosheet seeding and gel-free secondary growth is described. This process produces selective molecular sieve films that are as thin as 100 nm and exhibit record high permeances for xylene- and bu ...

2015

Effect of advanced oxidation processes on the micropollutants and the effluent organic matter contained in municipal wastewater previously treated by three different secondary methods

César Pulgarin, Dominique Grandjean, Luiz Felippe De Alencastro, Stefanos Giannakis, Franco Alejandro Gamarra Vives, Anoys Magnet

In this study, wastewater from the output of three different secondary treatment facilities (Activated Sludge, Moving Bed Bioreactor and Coagulation-Flocculation) present in the municipal wastewater treatment plant of Vidy, Lausanne (Switzerland), was furt ...

Elsevier2015

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