Concept
Rétrovirus endogène
Publications associées (49)
KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos
Transposable elements (TEs), also called jumping genes, are genetic elements capable of changing their position within the genome of their host. They make up large fractions of genomes, including 45% of human DNA content, according to current estimates.
S ...
EPFL2021The influence of human genetic variation on Epstein–Barr virus sequence diversity
Jacques Fellay, Dylan Lawless, Olivier Noël Marie Naret, Christian Hammer, Sina Rüeger
Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imp ...
2021Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression
Didier Trono, Priscilla Turelli, Alexandre Coudray
Gene expression aberration is a hallmark of cancers, but the mechanisms underlying such aberrations remain unclear. Human endogenous retroviruses (HERVs) are genomic repetitive elements that potentially function as enhancers. Since numerous HERVs are epige ...
AMER ASSOC ADVANCEMENT SCIENCE2020Human T-Cell Lymphotropic Virus Type 1 Transactivator Tax Exploits the XPB Subunit of TFIIH during Viral Transcription
Human T-cell lymphotropic virus type 1 (HTLV-1) Tax oncoprotein is required for viral gene expression. Tax transactivates the viral promoter by recruiting specific transcription factors but also by interfering with general transcription factors involved in ...
AMER SOC MICROBIOLOGY2020Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
Didier Trono, Bart Deplancke, Priscilla Turelli, Christian Axel Wandall Thorball, Julien Léonard Duc, Charlène Mireille Raymonde Raclot, Alexandre Coudray, Julien Paul André Pontis, Delphine Yvette L Grun, Christopher James Playfoot, Evgeniia Pankevich
In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influen ...
2020KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...
2020A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family
Didier Trono, Priscilla Turelli, Charlène Mireille Raymonde Raclot
TRIM28 (also known as KAP1 or TIF1β) is the universal co-repressor of the Krüppel-associated box-containing zinc finger proteins (Krab-ZFPs), the largest family of transcription factors in mammals. During early embryogenesis, TRIM28 mediates the transcript ...
2019Mild inborn errors of metabolism in commonly used inbred mouse strains
Johan Auwerx, Wei Zhang, Evan Graehl Williams
Inbred mouse strains are a cornerstone of translational research but paradoxically many strains carry mild inborn errors of metabolism. For example, alpha-aminoadipic acidemia and branched-chain ketoacid dehydrogenase deficiency are known in C57BL/6J mice. ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019A modeling approach to estimate the solar disinfection of viral indicator organisms in waste stabilization ponds and surface waters
Tamar Kohn, Michael Jon Mattle
Sunlight is known to be a pertinent factor governing the infectivity of waterborne viruses in the environment. Sunlight inactivates viruses via endogenous inactivation (promoted by absorption of UVB sunlight by the virus) and exogenous processes (promoted ...
Elsevier2016Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues
Didier Trono, Priscilla Turelli, Julien Léonard Duc, Sandra Eloise Kjeldsen, Marco Cassano, Michaël Imbeault, Gabriela Ecco, Annamaria Kauzlaric, Helen Mary Rowe, Andrea Coluccio
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a ...
Cell Press2016