Concept

Anticorps neutralisant

Publications associées (134)

Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor

We and others have previously observed that the antiviral effects of autocrine interferon (IFN)-alpha/beta activity cannot be abolished by neutralizing antibodies, even when present to a large excess. This raises the possibility that the major part of auto ...

1995

Cd40 Ligand Has Potent Antiviral Activity

Michel Aguet

For B cells to make antibodies against most antigens, they require help from T cells. T cell help is delivered as two signals to the B cell, one of which is via CD40 and the other can be through receptors for any of a variety of soluble cytokines. We have ...

1995

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

Michel Aguet

The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the ...

1995

Interferon gamma receptor deficient mice are resistant to endotoxic shock

Michel Aguet

Antibody neutralization studies have established interferon gamma (IFN-gamma) as a critical mediator of endotoxic shock. The advent of IFN-gamma receptor negative (IFN gamma R-/-) mutant mice has enabled a more direct assessment of the role of IFN-gamma in ...

1994

Behavioral factors in stress-induced immunomodulation

Maria del Carmen Sandi Perez

Individual differences in the exploratory response to novelty were found to be related with the vulnerability to develop stress-induced immunological alterations. We studied the effect of exposure to inescapable shock on antibody formation against sheep re ...

1992

Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat

Henry Markram

A monoclonal antibody to the nerve growth factor receptor (NGFR) (IgG 192) was used to visualize differences in immunohistochemical labeling of young (10 months) and old (35 months) rats. Three parameters were analyzed; cell counts, immunoreactive cross-se ...

1990

Designing CD4 immunoadhesins for AIDS therapy

Florian Maria Wurm

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to blo ...

1989

Polyclonal rearrangements of the T-cell receptor beta-chain in fatal angioimmunoblastic lymphadenopathy

Lukas Kühn

Genomic rearrangement of germline T-cell antigen receptor (TcR) and immunoglobulin (Ig) genes was studied by Southern blot analysis in seven patients with angioimmunoblastic lymphadenopathy (AILD). In three cases clinically suspected of transformation into ...

1989

[Circulating interferon in patients with systemic lupus erythematosus. A prospective study]

Michel Aguet

The serum levels of interferon (IFN) were measured in 31 patients with systemic lupus erythematosus (SLE). Among the 31 patients, 8 (25%) showed IFN in the sera: in 4 patients IFN titers of 16 U/ml, and in the other 4 patients titers of greater than or equ ...

1986

Antibodies recognizing different domains of the polymeric immunoglobulin receptor

Lukas Kühn

The receptor responsible for the transepithelial transport of IgA dimer antibodies is a transmembrane glycoprotein known as membrane secretory component (SCm). During transport, the membrane anchoring domain is cleaved and the ectoplasmic domain of the rec ...

1985

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