Bioidentical hormone replacement therapyBioidentical hormone replacement therapy (BHRT), also known as bioidentical hormone therapy (BHT) or natural hormone therapy, is the use of hormones that are identical on a molecular level with endogenous hormones in hormone replacement therapy. It may also be combined with blood and saliva testing of hormone levels, and the use of pharmacy compounding to obtain hormones in an effort to reach a targeted level of hormones in the body. A number of claims by some proponents of BHT have not been confirmed through scientific testing.
Membrane progesterone receptorMembrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Unlike the progesterone receptor (PR), a nuclear receptor which mediates its effects via genomic mechanisms, mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades.
Cellule de la granulosaLa granulosa est une couche de cellules folliculeuses granuleuses entourant l'ovocyte et la cavité liquidienne du follicule ovarien et responsable de la sécrétion de la progestérone durant la d'un cycle ovarien (corps jaune périodique) ou durant les quatre premiers mois de la grossesse (corps jaune gravidique), mais aussi des œstrogènes au cours du cycle. Au du cycle, a lieu un pic de LH et de FSH (hormone gonadotrophine : sécrétées par l'hypophyse) : c'est l'ovulation, ce qui provoquera indirectement une forte hausse de la production d’œstrogène.
EthylestrenolEthylestrenol, also known as ethyloestrenol or ethylnandrol and sold under the brand names Maxibolin and Orabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used in the past for a variety of indications such as to promote weight gain and to treat anemia and osteoporosis but has been discontinued for use in humans. It is still available for veterinary use in Australia and New Zealand however. It is taken by mouth.
NoréthandroloneLa norethandrolone est une molécule appartenant à la classe des stéroïdes anabolisants. Elle est indiquée en France dans le traitement de l'aplasie médullaire. Elle ne semble plus commercialisée qu'en France en 2020 L'indication de l'autorisation de mise sur le marché, délivrée en 1960, est l'aplasie médullaire, une pathologie correspondant à la cessation de la synthèse de nouvelles cellules sanguines dans la moelle osseuse.
MéthyltriénoloneMetribolone (developmental code R1881, also known as methyltrienolone) is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical use but has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR. More precisely, metribolone is the 17α-methylated derivative of trenbolone.
TrestoloneTrestolone, also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low testosterone levels in men but has never been marketed for medical use. It is given as an implant that is placed into fat. As trestolone acetate, an androgen ester and prodrug of trestolone, the medication can also be given by injection into muscle.
