Concept
Protéome
Publications associées (53)
Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles
Alexey Sapozhnik, Samuel Jones
JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...
Washington2023Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022Assessing normalization methods in mass spectrometry-based proteome profiling of clinical samples
Background: Large-scale proteomic studies have to deal with unwanted variability, especially when samples originate from different centers and multiple analytical batches are needed. Such variability is typically added throughout all the steps of a clinica ...
ELSEVIER SCI LTD2022Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii
Bruno Lemaitre, Samuel Rommelaere, Fanny Schüpfer, Florent François Masson, Alice Marra
Insects are frequently infected with heritable bacterial endosymbionts. Endosymbionts have a dramatic impact on their host physiology and evolution. Their tissue distribution is variable with some species being housed intracellularly, some extracellularly ...
2021DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies
Nicolas Jean Philippe Guex, Murielle Bochud, Cristian Carmeli, Aurélien Thomas, Tiziana Caputo
As a powerful phenotyping technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory effect in various biological processes. While ...
2021The functional proteome landscape of Escherichia coli
Camille Véronique Bernadette Goemans
Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3,4,5,6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar ...
2020Exploration of human cerebrospinal fluid: A large proteome dataset revealed by trapped ion mobility time-of-flight mass spectrometry
Cerebrospinal fluid (CSF) is a biofluid in direct contact with the brain and as such constitutes a sample of choice in neu-rological disorder research, including neurodegenerative dis-eases such as Alzheimer or Parkinson. Human CSF has still been less stud ...
ELSEVIER2020Progress and pitfalls of using isobaric mass tags for proteome profiling
Introduction: Quantitative proteomics using mass spectrometry is performed via label-free or label-based approaches. Labeling strategies rely on the incorporation of stable heavy isotopes by metabolic, enzymatic, or chemical routes. Isobaric labeling uses ...
TAYLOR & FRANCIS LTD2020Mitochondrial ph probe
Anders Meibom, Matthias Lütolf, Gennady Nikitin
The present invention relates to dual fluorophore ratiometric mitochondrial pH probes, their uses and their manufacture. ...
2019Functional characterization of 3D protein structures informed by human genetic diversity
Amalio Telenti, Istvan Bartha, Julia di Iulio
Sequence variation data of the human proteome can be used to analyze 3D protein structures to derive functional insights. We used genetic variant data from nearly 140,000 individuals to analyze 3D positional conservation in 4,715 proteins and 3,951 homolog ...
PNAS2019