Concept

Phospholipide

Publications associées (82)

Bridging across length scales: Multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

We show that a two-step process, involving spontaneous self-assembly of lipids and apolipoproteins and surface patterning, produces single, supported lipid bilayers over two discrete and independently adjustable length scales. Specifically, an aqueous phas ...

American Chemical Society (ACS)2008

Transition from Nanodomains to Microdomains Induced by Exposure of Lipid Monolayers to Air

Dusan Vobornik

The morphology of monolayers prepared from ternary lipid mixtures that have coexisting fluid phases has been examined by atomic force microscopy for samples transferred to mica before and after exposure to air. Mixtures of 1,2-dioleoyl- sn-glycero-3-phosph ...

Elsevier2007

Lipid membranes for the fabrication of functional micro- and nano-structures

Gopakumar Gopalakrishnan

The central goal of this thesis work is to fabricate novel, functional fluorescent nanostructures in confined systems offered by phospholipid membranes, which are known to have highly ordered, thermotropic and lyotropic structures. In separate approaches, ...

EPFL2006

Stability of Ag nanoparticles dispersed in amphiphilic organic matrix

Philippe Buffat, Elena Suvorova Buffat

Nano- and thin-film technologies based on novel systems associating metals particles to polymer matrix open a broad range of different applications. Such composites were found to be more efficient and safe, for instance, in biomedical needs. The Ag/poly(N- ...

2005

A molecular view of cholesterol-induced condensation in a lipid monolayer

Sylvie Roke, Michael Müller

We investigate the interrnolecular interactions in a mixed phospholipid/cholesterol monolayer using the surface-specific technique of vibrational sum frequency generation. This technique allows us to monitor the conformational and orientational order in th ...

2004

Rafts can trigger contact-mediated secretion of bacterial effectors via a lipid-based mechanism

Françoise Gisou van der Goot Grunberg

Infection by the Gram-negative bacterial pathogen Shigella flexneri depends on its ability to invade host cells. Bacterial engulfment requires a functional type III secretion system (TTSS) allowing the translocation into host cells of bacterial effectors t ...

2004

Two-phase partition profiling of drugs and ionisable compounds

Lipophilicity of compounds with therapeutic interest represents one of the most important physicochemical parameters in predicting and interpreting transport processes across biological barriers. This property is commonly measured as a drug | membrane part ...

EPFL2004

Peptide functionalized poly(L-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma

Jeffrey Alan Hubbell

The graft copolymer poly(L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) and its RGD- and RDG-functionalized derivs. (PLL-g-PEG/PEG-peptide) were assembled from aq. solns. on titanium (oxide) surfaces. The polymers were characterized by NMR in order to d ...

2003

The glycan core of GPI-anchored proteins modulates aerolysin binidng but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Sensitivity of mammalian cells to the bacterial toxin aerolysin is due to the presence at their surface of glycosylphosphatidyl inositol (GPI)-anchored proteins which act as receptors. Using a panel of mutants that are affected in the GPI biosynthetic path ...

2002

A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

Steinunn Baekkeskov Hanahan

the signals involved in axonal trafficking and presynaptic clustering are poorly defined. Here we show that targeting of the -aminobutyric acid–synthesizing enzyme glutamate decarboxylase 65 (GAD65) to presynaptic clusters is mediated by its palmitoylated ...

Rockefeller University Press2002

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