Publications associées à Rhodopsine

Features integrate along a motion trajectory when object integrity is preserved

Michael Herzog, Leila Drissi Daoudi - Kleinbauer

Information about a moving object is usually poor at each retinotopic location because photoreceptor activation is short, noisy, and affected by shadows, reflections of other objects, and so on. Integration across the motion trajectory may yield a much bet ...

2021

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naïg Aurelia Ludmilla Chenais

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

EPFL2021

Organic semiconductors for light-mediated neuromodulation

Diego Ghezzi, Danashi Imani Medagoda

There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges fo ...

SPRINGERNATURE2021

The Photoisomerization Pathway(s) of Push‐Pull Phenylazoheteroarenes

Anne-Clémence Corminboeuf, Sergio Vela Llausi

Azoheteroarenes are the most recent derivatives targeted to further improve the properties of azo‐based photoswitches. Their light‐induced mechanism for trans‐cis isomerization is assumed to be very similar to that of the parent azobenzene. As such, they i ...

2020

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...

2021

Discrete windows of feature integration

Michael Herzog, Adrien Christophe Doerig, Leila Drissi Daoudi - Kleinbauer

A car drives through the night. It is hard to estimate its color from single photoreceptor activity because photoreceptor activation is short and noisy. An efficient way to estimate the color is to average photoreceptor activities along the car’s motion tr ...

SAGE PUBLICATIONS LTD2019

A design methodology for charge-balanced stimulators based on anodic current variation monitoring

Alexandre Schmid, Reza Ranjandish

Charge balancing is a major safety concern in neural and functional electrical stimulation. This paper presents a novel and safe active charge balancing design methodology in which, after each cathodic and anodic stimulation pulse, the value of the remaini ...

2019

How Rhodopsin Tunes the Equilibrium between Protonated and Deprotonated Forms of the Retinal Chromophore

Ursula Röthlisberger, Siri Camee van Keulen, Alicia Solano

Rhodopsin is a photoactive G-protein-coupled receptor (GPCR) that converts dim light into a signal for the brain, leading to eyesight. Full activation of this GPCR is achieved after passing through several steps of the protein's photoactivation pathway. Ke ...

2017

Mechanism of ultrafast non-reactive deactivation of the retinal chromophore in non-polar solvents

Goran Zgrablic

The photoisomerization of the all-trans protonated Schiff base of retinal (SBR+) in solution is highly inefficient. The present theoretical and experimental investigation aims at disclosing the mechanisms of ultrafast, non-reactive relaxation of SBR+ that ...

Royal Soc Chemistry2017

Computational Investigation of Intracellular Signalling Cascades : from G-Protein-Coupled Receptors to Adenylyl Cyclase

Siri Camee van Keulen

In order to adjust to changes in the environment, cells can communicate via signalling cascades. A common pathway for intercellular communication is the G-protein-coupled- receptor (GPCR) signal transduction cascade which is triggered by a (chemical or phy ...

EPFL2017