Concept

Clamp euglycémique hyperinsulinémique

Publications associées (26)

Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion

GLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric and die within the first 3 weeks of life. Their endocrine pancreas shows a loss of first phase glucose-stimulated insulin secretion (GSIS) and inverse alpha to beta cell ...

2000

Effect of acute hyperglycemia on visual cortical activation as measured by functional MRI

Rolf Gruetter

To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycem ...

2000

Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes

Johan Auwerx

Peroxisome proliferator-activated receptor (PPAR)-gamma is one of the key actors of adipocyte differentiation. This study demonstrates 1) that PPAR-gamma mRNA expression is not altered in subcutaneous adipose tissue (n = 44) or in skeletal muscle (n = 19) ...

1999

Steady-state cerebral glucose concentrations and transport in the human brain

Rolf Gruetter

Understanding the mechanism of brain glucose transport across the blood- brain barrier is of importance to understanding brain energy metabolism. The specific kinetics of glucose transport nave been generally described using standard Michaelis-Menten kinet ...

1998

The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue

Johan Auwerx

The regulation of ob gene expression in abdominal subcutaneous adipose tissue was investigated using a reverse transcription-competitive PCR method to quantify the mRNA level of leptin. Leptin mRNA level was highly correlated with the body mass index of 26 ...

American Society for Clinical Investigation1996

1H NMR studies of glucose transport in the human brain

Rolf Gruetter

The difference between 1H nuclear magnetic resonance (NMR) spectra obtained from the human brain during euglycemia and during hyperglycemia is depicted as well-resolved glucose peaks. The time course of these brain glucose changes during a rapid increase i ...

1996

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