Radiothérapie externe | EPFL Graph Search

thumb|Mise en place d'une patiente pour un traitement de cancer du sein par un accélérateur linéaire d'électrons par radiothérapie externe. La radiothérapie externe est une technique de radiothérapie reposant sur la localisation d'un faisceau de particules sur une partie du patient. Elle est qualifiée d'externe puisque la source des particules est à l'extérieur du corps, contrairement à la curiethérapie, d'invention plus récente, où les sources sont introduites dans le patient. La radiothérapie externe exploite principalement des faisceaux de photons, au moyen d'un télécobalt ou d'un accélérateur linéaire de particules, ceux-ci permettant également l'emploi d'électrons. D'autres techniques mobilisent des faisceaux de neutrons, de protons ou d'ions lourds, tel le carbone. Notes et références Annexes Articles connexes

Hadronthérapie
Protonthérapie
Radiochirurgie
Accélération laser-plasma
Radiothérapie à l'iode 131

Catégorie:Physique méd

Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis

Natsuko Imaizumi

Radiotherapy is a widely used treatment option in cancer. However, recent evidence suggests that doses of ionizing radiation (IR) delivered inside the tumor target volume, during fractionated radiotherapy, can promote tumor invasion and metastasis. Furthermore, the tissues that surround the tumor area are also exposed to low doses of IR that are lower than those delivered inside the tumor mass, because external radiotherapy is delivered to the tumor through multiple radiation beams, in order to prevent damage of organs at risk. The biological effects of these low doses of IR on the healthy tissue surrounding the tumor area, and in particular on the vasculature remain largely to be determined. We found that doses of IR lower or equal to 0.8 Gy enhance endothelial cell migration without impinging on cell proliferation or survival. Moreover, we show that low-dose IR induces a rapid phosphorylation of several endothelial cell proteins, including the Vascular Endothelial Growth Factor (VEGF) Receptor-2 and induces VEGF production in hypoxia mimicking conditions. By activating the VEGF Receptor-2, low-dose IR enhances endothelial cell migration and prevents endothelial cell death promoted by an anti-angiogenic drug, bevacizumab. In addition, we observed that low-dose IR accelerates embryonic angiogenic sprouting during zebrafish development and promotes adult angiogenesis during zebrafish fin regeneration and in the murine Matrigel assay. Using murine experimental models of leukemia and orthotopic breast cancer, we show that low-dose IR promotes tumor growth and metastasis and that these effects were prevented by the administration of a VEGF receptor-tyrosine kinase inhibitor immediately before IR exposure. These findings demonstrate a new mechanism to the understanding of the potential pro-metastatic effect of IR and may provide a new rationale basis to the improvement of current radiotherapy protocols.

Public Library of Science2010

Preliminary Study of a Solar Trough/Tower Power Plant

Jorge López Moreno

The possibility of combining both the advantages of a solar tower thermal power plant and of a solar parabolic trough power plant could be interesting from an energetic point of view as well from an economic point of view. The preliminary study of this combination feasibility is the goal of this project. The study of the project viability consist first of all on the modeling of the trough system, the energy balance of the parabolic troughs will be established at first. Secondly, and choosing a perfect solar day simulating a day when the solar radiation is rather stable, with no cloudy periods along the day, the power available from the trough plant can be calculated. Once we have estimated the power that we can introduce into the cycle of the tower plant, the main issue consists on how and where it is better to use this energy in the cycle. Several possibilities seem to be interesting a priori, however a more detailed study of each one is to be done in order to get to the most economic and efficient layout. The work related to the tower thermal power plant will be done taking as starting point the master thesis of James Spelling, who did an incredible work in this field and whose work will be a valuable help to continue the research on the proposed concept in this project of combining two plants, tower and trough. The main advantage of the tower design compared to the parabolic trough design is the higher temperature. As it will be explained further, thermal energy at higher temperature can be converted more efficiently, the exergy efficiency is better. In terms of storage, the high temperature results in a cheaper and a more efficient storage system. Nevertheless, the set up of the field of heliostats is more complex than the set up of the parabolic trough lines even though the area for a trough plant must be previously flattened. The lower temperature level that entails an inconvenient itself for a parabolic trough power plant may become an advantage when combining both types of concentrating solar power plants. If the results are positive enough that it seems interesting to combine both types of power plants, another step forward will be done towards the use of the sun energy as a renewable source thus making it a more interesting choice for power generation. Sun potential has already shown as an important technology not only at the present time but also in the future. Commercial solar plants have already achieved levelized energy costs around 12-15 UScts/kWh, and the potential for cost reduction is expected to follow this trend even further, to costs as low as 5 UScts/kWh. In addition the taxes imposed for the non-green power should make even more interesting the use of concentrating solar power plants. The requirements of high beam normal radiation lead to a limited amount of suitable places where the implantation of this technology is possible. However many places exist on Earth where the conditions are perfectly adapted, we talk about regions such as United States (the country with more carbon dioxide emissions in the world), some regions in Mexico, North Africa, India, Australia, northeastern Brazil and some locations around the Mediterranean, especially in the south of Spain. The challenge is therefore set for a change in our energy production scheme.