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Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Discovery and Development of Hyperthermia-Enhanced Treatments for Malignant Skin and Uveal Melanomas

Mouna Hadiji

Melanomas are among the deadliest cancers, with a high predisposition to metastasis and a bad prognosis in their late stages. The effectiveness of current therapeutic regimens remains suboptimal, and despite initial successes, treatment resistance emerges ...

EPFL2023

Experimental Investigation of the Inelastic Cyclic Behavior of Concrete-Filled Double-Skin Tubular Beam-Columns with Corrugated Inner Skins and Ultrahigh-Strength Corner Tubes

Dimitrios Lignos, Mojtaba Farahi

This paper presents the experimental results from nine full-scale concrete-filled double-skin tubular (CFDST) beam-columns. The test specimens exploited two fabrication strategies, featuring either hollow steel inner skins with corrugated geometry or ultra ...

ASCE-AMER SOC CIVIL ENGINEERS2022

Gene expression patterns associated with multidrug therapy in multibacillary leprosy

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Thyago Leal Calvo

Multidrug therapy (MDT) has been successfully used in the treatment of leprosy. However, although patients are cured after the completion of MDT, leprosy reactions, permanent disability, and occasional relapse/reinfection are frequently observed in patient ...

FRONTIERS MEDIA SA2022

Ozone Initiates Human-Derived Emission of Nanocluster Aerosols

Dusan Licina, Shen Yang

Nanocluster aerosols (NCAs, particles

AMER CHEMICAL SOC2021

Wearable and Continuous Prediction of Passage of Time Perception for Monitoring Mental Health

David Atienza Alonso, Lara Orlandic, Adriana Arza Valdes

A person’s passage of time perception (POTP) is strongly linked to their mental state and stress response, and can therefore provide an easily quantifiable means of continuous mental health monitoring. In this work, we develop a custom experiment and Machi ...

2021

Soft Touch using Soft Pneumatic Actuator-Skin as a Wearable Haptic Feedback Device

Jamie Paik, Harshal Arun Sonar, Jian-Lin Huang

Understanding the external environment depends heavily on vision, audition, and touch. Like vision and audition, the human sense of touch is complex. Tactile perception is composed of multiple fundamental and physical experiences felt as changes in stiffne ...

2021

Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning

Hubert Girault, Horst Pick, Natalia Gasilova, Andreas Stephan Lesch, Milica Jovic, Yingdi Zhu, Tzu-En Lin

Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detec ...

2021

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021