Concept

Canal sodium

Publications associées (451)

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Ying Shi, Jean-Denis Georges Emile Courcol, Armando Romani, Michele Migliore, Maurizio Ferdinando Pezzoli, Szabolcs Kali, Carmen Alina Lupascu, Christian Andreas Rössert, Olivier Richard Hagens, Rosanna Migliore, Luca Leonardo Bologna, Audrey Mercer, Stefano Maximiliano Antonel

Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal memb ...

PUBLIC LIBRARY SCIENCE2018

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

Henning Paul-Julius Stahlberg

Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction. The free energy difference of cyclic-nucleotide (cAMP/cGMP) binding/unbinding is translated into mechanical work to modulate the open/closed probabilit ...

Springer Science and Business Media LLC2018

Experimental Study of Tsunami-Like Waves Generated with a Vertical Release Technique on Dry and Wet Beds

Anton Schleiss, Michael Pfister, Davide Wüthrich, Ioan Nistor

Tsunamis, impulse waves, and dam failures are disasters that challenge humanity, often leading to massive casualties and extreme economic losses. The highly unsteady flow conditions generated by such events are often in the form of turbulent bores. The pur ...

2018

Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion

Hatice Altug, George Coukos, Xiaokang Li, Maria Soler Aznar

Single-cell analysis of cytokine secretion is essential to understand the heterogeneity of cellular functionalities and develop novel therapies for multiple diseases. Unraveling the dynamic secretion process at single-cell resolution reveals the real-time ...

2018

Size limitations on achieving tough and healable fibre reinforced composites through the use of thermoplastic nanofibres

Véronique Michaud, Amaël Maximilien Cohades, Lode Geeraard Daelemans

Phase-separated blends of epoxy and poly(ε-caprolactone) (PCL) provide crack repair in composites after a thermal treatment at 150 °C, but decrease the material’s fracture toughness. This article investigates the combination of healing with interlaminar fr ...

2018

Transport of suspended sediments under the influence of bank macro-roughness

Anton Schleiss, Mário Jorge Rodrigues Pereira Da Franca, Carmelo Juez Jiménez

River restoration works often include measures to promote morphological diversity and enhance habitat suitability. One of these measures is the creation of macro-roughness elements, such as lateral cavities and embayments, in the banks of channelized river ...

2018

On the Input-Degradedness and Input-Equivalence Between Channels

Rajai Nasser

A channel W is said to be input-degraded from another channel W' if W can be simulated from W' by randomization at the input. We provide a necessary and sufficient condition for a channel to be input-degraded from another one. We show that any decoder that ...

2017

Mapping the function of neuronal ion channels in model and experiment

Rajnish Ranjan, Alexander Kevin Seeholzer, Tim Vogels, William Francis Podlaski

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison o ...

Elife Sciences Publications Ltd2017

Continuous attractor working memory and provenance of channel models

Alexander Kevin Seeholzer

The brain is a complex biological system composed of a multitude of microscopic processes, which together give rise to computational abilities observed in everyday behavior. Neuronal modeling, consisting of models of single neurons and neuronal networks at ...

EPFL2017

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