Publications associées à Gène Hox

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Within land vertebrate species, snakes display extreme variations in their body plan, characterized by the absence of limbs and an elongated morphology. Such a particular interpretation of the basic vertebrate body architecture has often been associated wi ...

Elife Sciences Publications Ltd2016

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Denis Duboule, Jozsef Zakany, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Virginie Marcet

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...

National Academy of Sciences2016

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Denis Duboule, Leonardo Beccari, Anamaria Necsulea, Nicolas Lonfat, Edgardo Rodriguez Carballo, Nayuta Yakushiji

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets ...

Cold Spring Harbor Laboratory2016

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation

Antonio Carlos Alves Meireles Filho

Hox homeodomain transcription factors are key regulators of animal development. They specify the identity of segments along the anterior-posterior body axis in metazoans by controlling the expression of diverse downstream targets, including transcription f ...

Public Library of Science2016

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Denis Duboule, Fabrice Daniel Darbellay

Hox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was ...

Elsevier Academic Press Inc2016

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

Marianna Feretzaki

RNAi is a ubiquitous pathway that serves central functions throughout eukaryotes, including maintenance of genome stability and repression of transposon expression and movement. However, a number of organisms have lost their RNAi pathways, including the mo ...

Public Library of Science2016

A Fast and Exact Algorithm for the Exemplar Breakpoint Distance

Bernard Moret, Mingfu Shao

A fundamental problem in comparative genomics is to compute the distance between two genomes. For two genomes without duplicate genes, we can easily compute a variety of distance measures in linear time, but the problem is NP-hard under most models when ge ...

Mary Ann Liebert, Inc2016

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

Denis Duboule, Nicolas Lonfat

Hox genes encode transcription factors necessary for patterning the major developing anterior to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of this gene family were co-opted along with the emergence of novel body st ...

Elsevier2015

Visualizing the HoxD Gene Cluster at the Nanoscale Level

Denis Duboule, Suliana Manley, Aleksandr Benke, Pierre Raymond Fabre

Transcription of HoxD cluster genes in limbs is coordinated by two topologically associating domains (TADs), neighboring the cluster and containing various enhancers. Here, we use a combination of microscopy approaches and chromosome conformation capture t ...

2015

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Gène Hox

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

A Fast and Exact Algorithm for the Exemplar Breakpoint Distance

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model

Visualizing the HoxD Gene Cluster at the Nanoscale Level

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Chattez avec Graph Search

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Visualizing the HoxD Gene Cluster at the Nanoscale Level

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

A Fast and Exact Algorithm for the Exemplar Breakpoint Distance

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model